Cognitive performance in depressed older persons: the impact of vascular burden and remission. A two-year follow-up study

International Journal of Geriatric Psychiatry
Marij ZuidersmaRichard C Oude Voshaar

Abstract

Depression is associated with an increased risk of cognitive decline. The present study compared two-year change in cognitive performance between depressed older persons and a non-depressed control group, between remitted and non-remitted patients, and evaluated whether vascular burden at baseline was associated with more cognitive decline in depressed older persons. Depressed patients (n = 378) aged ≥60 were recruited from mental healthcare institutes and general practices, and a non-depressed control group (n = 132) was recruited from general practices. A DSM-IV depressive episode was established with the Composite International Diagnostic Interview, and processing speed, working memory, verbal memory and interference control were evaluated with three neurocognitive tasks at baseline and 2 years later. A modified Framingham Risk Score, ankle-brachial index, and history of a vascular event defined vascular burden at baseline. After adjusting for baseline cognitive performance, age, sex, and education level, depressed older persons had worse processing speed and verbal memory scores at follow-up than controls (regression coefficients: -0.172; p = 0.042 and -0.309; p = 0.001, respectively) but did not differ in the other two-cog...Continue Reading

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Citations

May 23, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Astrid LugtenburgRichard C Oude Voshaar
Nov 4, 2016·BMC Medicine·Howard J AizensteinOren Tene
Apr 2, 2021·Journal of Geriatric Psychiatry and Neurology·Marieke HenstraNathaly Rius Ottenheim

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