Cognitive safety of intracranial electrodes for epilepsy

Epilepsia
Kimford J MeadorBruce P Hermann

Abstract

Two recent articles in Epilepsia have raised concerns about adverse cognitive effects associated with intracranial electrode implantation. However, both studies have important limitations, and their results contrast with studies that report no adverse cognitive effects of intracranial electrodes for diagnosis or neurostimulation in epilepsy. Furthermore, no data are provided on the relative safety of depth electrodes implanted along the longitudinal axis of the hippocampus vs other electrode locations or types of electrodes. Instituting changes in the use of depth electrodes based solely on these 2 studies is not clinically indicated. Further research is needed.

References

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Jan 10, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M VelascoA L Velasco
Nov 25, 2003·Journal of the International Neuropsychological Society : JINS·Elisabeth ShermanKevin Farrell
Oct 4, 2005·Journal of Neuroscience Methods·Vadim S PolikovWilliam M Reichert
Aug 23, 2008·The Clinical Neuropsychologist·Deborah K AttixJeffrey T Barth
Apr 25, 2013·Annals of Neurology·Mohamad Z KoubeissiDominique M Durand
Jan 7, 2017·Seizure : the Journal of the British Epilepsy Association·Alexander I TrösterUNKNOWN SANTE Study Group
Dec 14, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Felice T SunMartha J Morrell

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Citations

May 3, 2019·Current Neurology and Neuroscience Reports·Andreu Massot-TarrúsSeyed M Mirsattari
Apr 30, 2021·Frontiers in Neurology·Daniel L DraneAmmar Kheder

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