Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial

Parkinson's Disease
Blake J LawrenceAndrea M Loftus

Abstract

This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group. Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up. The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge's g range = 0.01 to 1.75). More outcomes improved for the groups that received stand...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 1, 1989·Journal of Clinical and Experimental Neuropsychology·B WilsonR Hiorns
Jul 18, 2006·Journal of the Neurological Sciences·Paulo S BoggioFelipe Fregni
Oct 19, 2007·Journal of the International Neuropsychological Society : JINS·Dino MuslimovićRob J de Haan
Feb 20, 2008·Annals of Internal Medicine·Isabelle BoutronUNKNOWN CONSORT Group
Apr 3, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Javier PagonabarragaAlexandre Gironell
Jun 4, 2008·Neurology·D MuslimovicUNKNOWN CARPA Study Group
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Oct 23, 2009·Restorative Neurology and Neuroscience·Joshua O Goh, Denise C Park
Feb 23, 2010·International Psychogeriatrics·Loren MowszowskiSharon L Naismith
Mar 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Anna Prats ParísAngels Rusiñol Bayés
Nov 25, 2011·International Journal of Alzheimer's Disease·Raffaele NardoneStefan Golaszewski
Jan 26, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanMurat Emre
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Bob WoodsMartin Orrell
May 1, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Sharon L NaismithSimon J G Lewis
Oct 15, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer G GoldmanGlenn T Stebbins
Feb 21, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Antonio CerasaAldo Quattrone
Apr 9, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Brenna A CholertonKaren L Edwards
Jul 16, 2014·PloS One·Blake J LawrenceAndrea M Loftus
Aug 1, 2014·Brain : a Journal of Neurology·Cristina NombelaRoger A Barker
Sep 3, 2014·Neuroscience Letters·Deniz DorukFelipe Fregni
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Aug 25, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer G Goldman, Daniel Weintraub
Sep 22, 2016·Scientific Reports·Blake J LawrenceAndrea M Loftus
Jun 7, 2017·Neurorehabilitation and Neural Repair·Blake J LawrenceAndrea M Loftus

❮ Previous
Next ❯

Citations

Feb 27, 2020·The Cochrane Database of Systematic Reviews·Vasiliki OrgetaIracema Leroi
Oct 30, 2019·Journal of the International Neuropsychological Society : JINS·Junhong YuTatia M C Lee
Jun 26, 2020·Frontiers in Neuroscience·Jacky GangulyMandar Jog
Jun 17, 2020·Journal of Neuroengineering and Rehabilitation·Victor Spiandor BerettaRodrigo Vitório
Feb 2, 2021·Expert Review of Neurotherapeutics·Katarina RukavinaK Ray Chaudhuri
Apr 29, 2021·Dementia & Neuropsychologia·Nariana Mattos Figueiredo SousaSonia Maria Dozzi Brucki
Jun 9, 2021·Neuroscience·Alexandra Potvin-Desrochers, Caroline Paquette
Oct 26, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Vrinda Saxena, Arghya Pal

❮ Previous
Next ❯

Methods Mentioned

BETA
MDS

Software Mentioned

Smartbrain Pro
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.