Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD

Frontiers in Behavioral Neuroscience
Paul C P CurtinDaniela Brunner

Abstract

Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive deficits in the zQ175 KI Het (zQ175) mouse model of HD. In Experiment 1 we trained zQ175 mice in a fixed-ratio/progressive ratio (FR/PR) task to assay learning and motivational deficits. We found pronounced deficits in response rates and task engagement in naïve adult zQ175 mice (32-33 weeks age), while deficits in zQ175 mice trained from 6-7 weeks age were either absent or less severe. When those mice were re-tested as adults, FR/PR performance deficits were absent or otherwise less severe than deficits observed in naïve adult zQ175 relative to wild type (WT) mice. In Experiment 2, we used a Go/No-go operant task to assess the effects of early cognitive testing on response inhibition deficits in zQ175 mice. We found that zQ175 mice that began testing at 7-8 weeks did not exhibit deficits in Go/No-go testing, but when re-tested at 28-29 weeks age exhibited an initial impairment that diminished with training. These transient deficits were nonetheless mild relative to deficits observed among adult zQ175 mice withou...Continue Reading

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Citations

Dec 17, 2016·Journal of Huntington's Disease·Claudia Rangel-Barajas, George V Rebec
Aug 27, 2019·Frontiers in Neurology·Christopher J HeathBarbara J Sahakian
Mar 3, 2020·Frontiers in Neuroscience·Sonja Blumenstock, Irina Dudanova
Oct 20, 2018·Frontiers in Behavioral Neuroscience·Tuukka O PiiponniemiMaksym V Kopanitsa
May 17, 2019·Journal of Neurochemistry·Amy I Smith-DijakLynn A Raymond
Jul 25, 2018·Current Protocols in Neuroscience·Claudia Rangel-Barajas, George V Rebec
Jul 1, 2020·Neurobiology of Disease·Daniel K Wilton, Beth Stevens

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Methods Mentioned

BETA
transgenic

Software Mentioned

Med
SAS
PC IV

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