Cognitively Healthy Individuals Want to Know Their Risk for Alzheimer's Disease: What Should We Do?

Journal of Alzheimer's Disease : JAD
Shana D Stites

Abstract

Richard Milne and colleagues (2018) present the results of a study to discover what cognitively unimpaired research participants hope to gain by learning Alzheimer's disease (AD) biomarker results and the associated risk for AD dementia. Their results are useful to develop procedures to safely disclose AD biomarker results in prevention trials. They also foreshadow the ethical and pragmatic challenges of using AD biomarkers in routine clinical practice. What is currently known is largely from studies of cognitively unimpaired or mildly impaired individuals who learned they had genetic markers of AD. Little is known about learning biomarker results. Milne and colleagues found that participants expect they will routinely learn risk reduction strategies and have access to follow up care. Can we meet these expectations? Mixed evidence supports effective therapies for delaying symptoms of AD and virtually nonexistent evidence guides prevention of AD. Healthcare resources, including follow-up, are designed to manage patients who have clinical symptoms-not the potentially large numbers of unimpaired individuals. To meet these needs, researchers who disclose AD biomarker results to cognitively unimpaired research participants may have ...Continue Reading

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Citations

Nov 18, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Richard S IsaacsonRobert Krikorian
Nov 27, 2019·Current Opinion in Psychiatry·Miguel E RenteríaAmaranta Manrique de Lara
Aug 29, 2020·Der Nervenarzt·Silke SchicktanzScott Stock Gissendanner
Jul 18, 2018·Healthcare·Cara L BerkowitzRichard S Isaacson
Dec 19, 2020·Journal of Alzheimer's Disease : JAD·Dorothee HorstkötterSebastian Köhler
Mar 6, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Claire M EricksonLindsay R Clark

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