COGTIPS: a double-blind randomized active controlled trial protocol to study the effect of home-based, online cognitive training on cognition and brain networks in Parkinson's disease

BMC Neurology
Tim D van BalkomOdile A van den Heuvel

Abstract

Cognitive dysfunction is highly prevalent in Parkinson's disease (PD) and a large proportion of patients eventually develops PD-related dementia. Currently, no effective treatment is available. Cognitive training is effective in relieving cognitive dysfunctions in several -neurodegenerative- diseases, and earlier small-scale trials have shown positive results for PD. In this randomized controlled trial, we assess the efficacy of online home-based cognitive training, its long-term effects, as well as the underlying neural correlates in a large group of PD patients. In this double-blind randomized controlled trial we will include 140 non-demented patients with idiopathic PD that experience significant subjective cognitive complaints. Participants will be randomized into a cognitive training group and an active control group. In both groups, participants will individually perform an online home-based intervention for eight weeks, three times a week during 45 min. The cognitive training consists of thirteen games that focus on executive functions, attention and processing speed with an adaptive difficulty. The active control comprises three games that keep participants cognitively engaged without a training component. Participants ...Continue Reading

Associated Clinical Trials

Sep 30, 2016·Chris Vriend, PhD

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Citations

Feb 27, 2020·The Cochrane Database of Systematic Reviews·Vasiliki OrgetaIracema Leroi
Feb 23, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Marissa D ZwanNiels D Prins
Aug 20, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Chris VriendOdile A van den Heuvel

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Software Mentioned

Matlab
R
COGTIPS
Statistical Parametric Mapping ( SPM )
BrainGymmer
Excel
SPSS
FMRIB Software Library ( FSL )

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