May 24, 2013

COHELLP: collaborative randomized controlled trial on corticosteroids in HELLP syndrome

Reproductive Health
Leila KatzCOHELLP Study Group

Abstract

Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome is one of the most severe forms of preeclampsia and aggravates both maternal and perinatal prognosis. The systematic review available in Cochrane Library compared corticosteroid (dexamethasone, betamethasone, or prednisolone) given during pregnancy, just after delivery or in the postnatal period, or both before and after birth, with placebo or no treatment. Those receiving steroids showed significantly greater improvement in platelet counts which was greater for those receiving dexamethasone than those receiving betamethasone. There was no clear evidence of any effect of corticosteroids on substantive clinical outcomes. These benefits appear to be greater in Class I HELLP syndrome. To determine the effectiveness of dexamethasone for accelerating postpartum recovery in patients with Class I HELLP syndrome in a multicenter randomized controlled trial. The study is a triple blind randomized controlled trial including women with class I HELLP syndrome, and exclusion criteria were dexamethasone use in the last 15 days before diagnosis of HELLP syndrome; chronic use of corticosteroids; chronic diseases that alter laboratory parameters of HELLP Syndrome, such as chr...Continue Reading

  • References13
  • Citations11

References

  • References13
  • Citations11

Citations

Mentioned in this Paper

Laboratory Procedures
Betamethasone
Purpura
Coma (genus)
Corticosteroid [EPC]
Randomized Controlled Trial (Publication)
Chronic Disease
Prednisolone
Corticosteroids, topical for treatment of hemorrhoids and anal fissures
Chronic Liver Disease

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