Coherence and Coupling Functions Reveal Microvascular Impairment in Treated Hypertension

Frontiers in Physiology
Valentina TiccinelliAneta Stefanovska

Abstract

The complex interactions that give rise to heart rate variability (HRV) involve coupled physiological oscillators operating over a wide range of different frequencies and length-scales. Based on the premise that interactions are key to the functioning of complex systems, the time-dependent deterministic coupling parameters underlying cardiac, respiratory and vascular regulation have been investigated at both the central and microvascular levels. Hypertension was considered as an example of a globally altered state of the complex dynamics of the cardiovascular system. Its effects were established through analysis of simultaneous recordings of the electrocardiogram (ECG), respiratory effort, and microvascular blood flow [by laser Doppler flowmetry (LDF)]. The signals were analyzed by methods developed to capture time-dependent dynamics, including the wavelet transform, wavelet-based phase coherence, non-linear mode decomposition, and dynamical Bayesian inference, all of which can encompass the inherent frequency and coupling variability of living systems. Phases of oscillatory modes corresponding to the cardiac (around 1.0 Hz), respiratory (around 0.25 Hz), and vascular myogenic activities (around 0.1 Hz) were extracted and combi...Continue Reading

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Citations

Oct 28, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Tomislav StankovskiAneta Stefanovska
Oct 28, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Zeray HagosAneta Stefanovska
Oct 28, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·M RosenblumA Pikovsky
Jun 16, 2018·Frontiers in Physiology·Lingguo BuJianfeng Li
Mar 15, 2020·Scientific Reports·Eric ZakherHai-Ling Margaret Cheng
Sep 13, 2020·Environment International·Robert D MeadeGlen P Kenny
Feb 16, 2021·Frontiers in Physiology·Kenichiro Yoshida, Izumi Nishidate
Aug 30, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Irina V TikhonovaArina V Tankanag

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