Coherent concepts are computed in the anterior temporal lobes.

Proceedings of the National Academy of Sciences of the United States of America
Matthew A Lambon RalphEmily J Mayberry

Abstract

In his Philosophical Investigations, Wittgenstein famously noted that the formation of semantic representations requires more than a simple combination of verbal and nonverbal features to generate conceptually based similarities and differences. Classical and contemporary neuroscience has tended to focus upon how different neocortical regions contribute to conceptualization through the summation of modality-specific information. The additional yet critical step of computing coherent concepts has received little attention. Some computational models of semantic memory are able to generate such concepts by the addition of modality-invariant information coded in a multidimensional semantic space. By studying patients with semantic dementia, we demonstrate that this aspect of semantic memory becomes compromised following atrophy of the anterior temporal lobes and, as a result, the patients become increasingly influenced by superficial rather than conceptual similarities.

References

Nov 1, 1975·The Quarterly Journal of Experimental Psychology·E K Warrington
Dec 1, 1992·Brain : a Journal of Neurology·J R HodgesE Funnell
Feb 1, 1987·The Journal of Comparative Neurology·M A MoránM M Mesulam
Jul 1, 1985·Psychological Review·G L Murphy, D L Medin
Sep 19, 1996·Nature·R VandenbergheR S Frackowiak
Jun 24, 2000·Neuropsychologia·S BozeatJ R Hodges
Feb 14, 2003·Trends in Cognitive Sciences·Lawrence W. BarsalouChristine D. Wilson
May 14, 2003·Neuron·Ksenija MarinkovicEric Halgren
Feb 6, 2004·Psychological Review·Timothy T RogersKaralyn Patterson
Jun 17, 2005·Nature Reviews. Neuroscience·Friedemann Pulvermüller
Nov 23, 2005·NeuroImage·Peter J NestorJohn R Hodges
Sep 14, 2006·Annual Review of Psychology·Alex Martin
Nov 21, 2007·Nature Reviews. Neuroscience·Karalyn PattersonTimothy T Rogers
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gorana PobricMatthew A Lambon Ralph
Apr 11, 2008·Annals of the New York Academy of Sciences·Matthew A Lambon Ralph, Karalyn Patterson
May 24, 2008·Neuropsychologia·Anna M WoollamsKaralyn Patterson
Jul 16, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marco Catani, Michel Thiebaut de Schotten
Aug 6, 2008·Cerebral Cortex·Matthew A Lambon RalphElizabeth Jefferies
Jul 28, 2009·Journal of the International Neuropsychological Society : JINS·W Kyle Simmons, Alex Martin

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Citations

Jun 29, 2011·Journal of Molecular Neuroscience : MN·Phillip D Fletcher, Jason D Warren
Jul 1, 2011·Cognitive Neuropsychology·Myrna F Schwartz, Gary S Dell
Jul 1, 2011·Neuropsychological Rehabilitation·Nathalie BierUNKNOWN SemAssist Team
Oct 19, 2010·Brain : a Journal of Neurology·Matthew A Lambon RalphKaralyn Patterson
Aug 23, 2011·Brain : a Journal of Neurology·Sharpley HsiehJohn R Hodges
Jan 31, 2012·Brain : a Journal of Neurology·Matthew A Lambon RalphTimothy T Rogers
Jun 21, 2011·Cerebral Cortex·Teresa SchuhmannAlexander Thomas Sack
Nov 19, 2011·Cerebral Cortex·Emmanuelle VollePaul W Burgess
Jun 22, 2012·Proceedings. Biological Sciences·Josie BriscoeDavid Skuse
Dec 11, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthew A Lambon Ralph
Nov 10, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Rohani OmarJason D Warren
Jul 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew K LeonardEric Halgren
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander M ChanEric Halgren
Sep 27, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jakke TamminenPenelope A Lewis
Feb 13, 2014·Brain : a Journal of Neurology·Holly RobsonMatthew A Lambon Ralph
Dec 20, 2012·Brain : a Journal of Neurology·Paul HoffmanMatthew A Lambon Ralph
May 21, 2013·Brain Structure & Function·Miguel BurgaletaNúria Sebastián-Gallés
Sep 21, 2013·Journal of Cognitive Neuroscience·Ho Ming ChowAllen R Braun
Jan 23, 2016·Trends in Cognitive Sciences·Arjen StolkIvan Toni
Feb 19, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Phillip D FletcherJason D Warren
Dec 17, 2015·NeuroImage·Idan BlankEvelina Fedorenko
Jan 20, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Paul Hoffman, Sebastian Crutch
Dec 29, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sonya MehtaThomas Grabowski
Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Paul HoffmanAnna M Woollams
Oct 25, 2014·Brain Structure & Function·Pablo CampoAntonio Gil-Nagel
Apr 4, 2013·Neuroscience and Biobehavioral Reviews·Carol A Seger, Erik J Peterson
Oct 27, 2015·Annals of the New York Academy of Sciences·Grace E RiceMatthew A Lambon Ralph
Jan 25, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tim Shallice, Miran Skrap
Dec 17, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David KemmererDaniel Tranel
Oct 20, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Peter ZeidmanEleanor A Maguire
Aug 19, 2015·Journal of Cognitive Neuroscience·Sarah H SolomonSharon L Thompson-Schill
Apr 18, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jingyi Geng, Tatiana T Schnur
Apr 18, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Y ChenM A Lambon Ralph

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