Coherent inspiratory oscillation of cranial nerve discharges in perfused neonatal cat brainstem in vitro

The Journal of Physiology
F KatoM Denavit-Saubié

Abstract

1. To understand the neural organization of respiratory movement control and its developmental transformation, we studied the temporal characteristics of inspiratory activities, especially nerve-to-nerve short-term synchronization, in an in vitro preparation of the isolated, perfused brainstem of kittens aged 0-14 days (postnatal day (P) 0-14). 2. In the inspiratory discharges of facial, vagus, glossopharyngeal and hypoglossal nerves, a stable oscillation with a period of 30-40 ms (i.e. approximately 30 Hz) was observed in all preparations examined. In addition, we demonstrated that this oscillation presents a strong short-term synchrony between distinct inspiratory nerves. This nerve-to-nerve synchronization was already apparent at approximately 12 h after birth. The degree of synchronization as evaluated by coherence spectral analysis was larger than 0.85 in all cases at any age examined. 3. This nerve-to-nerve coherence was not affected by changes in temperature (28-36 degrees C), whereas respiratory rate, oscillation frequency and oscillation amplitude as estimated by power spectral analysis were highly temperature sensitive. 4. The nerve-to-nerve synchronization, as well as the approximately 30 Hz oscillation, remained unc...Continue Reading

Citations

Nov 10, 2013·Respiratory Physiology & Neurobiology·Brigitte QuenetGinette Horcholle-Bossavit
Apr 3, 2013·Respiratory Physiology & Neurobiology·Michael George Zaki Ghali, Vitaliy Marchenko
Sep 15, 2004·Experimental Physiology·Walter M St-JohnJ C Leiter
Oct 22, 2004·Journal of Neurophysiology·Marvin H O'NealIrene C Solomon
Jul 11, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vitaliy Marchenko, Robert F Rogers
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vitaliy MarchenkoMorton I Cohen
Oct 13, 2017·Journal of Neurophysiology·Michael George Zaki Ghali
Apr 30, 1999·Physiological Reviews·G Hilaire, B Duron
Apr 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Walter M St-John, J C Leiter

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