PMID: 11900197Mar 20, 2002Paper

Coherent thermal wave imaging of subsurface chromophores in biological materials

Physics in Medicine and Biology
Sergev A TelenkoThomas E Milner

Abstract

Thermal wave imaging of discrete subsurface chromophores in biological materials is reported using a phase sensitive coherent detection technique applied to recorded infrared (IR) images. We demonstrate that utilization of a periodically modulated laser source for thermal wave excitation and coherent detection applied to each pixel may be used to compute images of thermal wave amplitude and phase at the laser modulation frequency. In comparison to recorded IR images, the narrow-band detection technique significantly improves the quality of thermal wave amplitude images of subsurface chromophores in biological materials. Additionally, the technique provides phase information, which may be used to estimate chromophore depth in tissue. Application of the technique is demonstrated using tissue phantoms and in vivo biological models. We present a theoretical analysis and computer simulations that demonstrate the effect of tissue optical and thermal properties on thermal wave amplitude and phase. In comparison to the pulsed photothermal technique, coherent thermal wave imaging of subsurface chromophores in tissue for diagnostic applications allows reduction of peak incident laser fluence by as much as four orders of magnitude and is ...Continue Reading

References

Nov 1, 1979·Microvascular Research·H D PapenfussF A Treese
Jun 1, 1992·Physics in Medicine and Biology·S A PrahlR R Anderson
Jul 1, 1995·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·T E MilnerJ S Nelson
Nov 1, 1994·The Journal of Investigative Dermatology·S KimelM W Berns
Mar 7, 2001·Physics in Medicine and Biology·S A TelenkovT E Milner
Mar 1, 1973·Applied Optics·G M Hale, M R Querry

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Citations

Apr 26, 2005·Journal of Biomedical Optics·Alexander SviridovAmir H Gandjbakhche
Apr 2, 2009·The Review of Scientific Instruments·Nima Tabatabaei, Andreas Mandelis
Jun 6, 2008·The Journal of the Acoustical Society of America·Natalie Baddour
Feb 20, 2004·Physics in Medicine and Biology·Sergey A TelenkovThomas E Milner
Sep 17, 2003·Physics in Medicine and Biology·F LahjomriR M Leblanc

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