Cohesin and human disease: lessons from mouse models

Current Opinion in Cell Biology
Vijay Pratap Singh, Jennifer L Gerton

Abstract

Cohesin is an evolutionarily conserved large ring-like multi-subunit protein structure that can encircle DNA. Cohesin affects many processes that occur on chromosomes such as segregation, DNA replication, double-strand break repair, condensation, chromosome organization, and gene expression. Mutations in the genes that encode cohesin and its regulators cause human developmental disorders and cancer. Several mouse models have been established with the aim of understanding the cohesin mediated processes that are disrupted in these diseases. Mouse models support the idea that cohesin is essential for cell division, but partial loss of function can alter gene expression, DNA replication and repair, gametogenesis, and nuclear organization.

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Citations

Jan 29, 2016·Current Opinion in Genetics & Development·Erwan WatrinKerstin S Wendt
Apr 28, 2016·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Shimako KawauchiAnne L Calof
May 27, 2016·Molecular Biology of the Cell·Prashant K MishraMunira A Basrai
Feb 10, 2016·The Journal of Biological Chemistry·Yu-Jiao LiuWei Li
Mar 16, 2019·Frontiers in Cell and Developmental Biology·Alex PezzottaAnna Pistocchi
Nov 8, 2017·Cellular and Molecular Life Sciences : CMLS·Liron DavisEvan Elliott
Jan 7, 2021·Current Genetics·Anjali PathaniaItay Onn
Aug 26, 2021·Molecular Biology of the Cell·Prashant K MishraMunira A Basrai

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