Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadherin Flamingo

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Kousuke MouriTadashi Uemura

Abstract

Planar cell polarity (PCP) refers to the coordination of global organ axes and individual cell polarity in vertebrate and invertebrate epithelia. Mechanisms of PCP have been best studied in the Drosophila wing, in which each epidermal cell produces a single wing hair at the distal cell edge, and this spatial specification is mediated by redistribution of the core group proteins, including the seven-pass transmembrane cadherin Flamingo/Starry night (Fmi/Stan), to selective plasma membrane domains. Through genetic screening, we found that a mutation of the SMC3 gene caused dramatic misspecification of wing hair positions. SMC3 protein is one subunit of the cohesin complex, which regulates sister chromatid cohesion and also plays a role in transcriptional control of gene expression. In the SMC3 mutant cells, Fmi appeared to be upregulated by a posttranscriptional mechanism(s), and this elevation of Fmi was at least one cause of the PCP defect. In addition to the PCP phenotype, the loss of the cohesin function affected wing morphogenesis at multiple levels: one malformation was loss of the wing margin, and this was most likely a result of downregulation of the homeodomain protein Cut. At the cellular level, apical cell size and hex...Continue Reading

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Citations

Nov 10, 2013·PLoS Genetics·Merel A W OortveldAnnette Schenck
Jan 10, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kousuke MouriTadashi Uemura
Mar 26, 2014·Neuroscience and Biobehavioral Reviews·Monique van der VoetAnnette Schenck
Sep 11, 2020·Development·Hirotaka TaoSevan Hopyan

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