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Cohesin mutations in myeloid malignancies: underlying mechanisms

Experimental Hematology & Oncology

Jun 7, 2014

Bryony LeekeJulia A Horsfield

Abstract

Recently, whole genome sequencing approaches have pinpointed mutations in genes that were previously not associated with cancer. For Acute Myeloid Leukaemia (AML), and other myeloid disorders, these approaches revealed a high prevalence of mutations in genes encoding the chromosome cohe...read more

Mentioned in this Paper

Embryo
Short Interspersed Nucleotide Elements
Biochemical Pathway
RUNX1 gene
Cohesin Complex
Genome
DNA Repair
Cohesins
SMC1A gene
NPM1 wt Allele
3
71
Paper Details
References
  • References57
  • Citations14
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  • References57
  • Citations14
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Cohesin mutations in myeloid malignancies: underlying mechanisms

Experimental Hematology & Oncology

Jun 7, 2014

Bryony LeekeJulia A Horsfield

PMID: 24904756

DOI: 10.1186/2162-3619-3-13

Abstract

Recently, whole genome sequencing approaches have pinpointed mutations in genes that were previously not associated with cancer. For Acute Myeloid Leukaemia (AML), and other myeloid disorders, these approaches revealed a high prevalence of mutations in genes encoding the chromosome cohe...read more

Mentioned in this Paper

Embryo
Short Interspersed Nucleotide Elements
Biochemical Pathway
RUNX1 gene
Cohesin Complex
Genome
DNA Repair
Cohesins
SMC1A gene
NPM1 wt Allele
3
71

Feeds With Similar Papers

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.

Related Papers

British Journal of Haematology

The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q)

British Journal of HaematologyJune 17, 2014
Megan E McNerneyKevin P White
Mutation Research

Cohesinopathies: One ring, many obligations

Mutation ResearchSeptember 13, 2008
Adrian J McNairn, Jennifer L Gerton
Paper Details
References
  • References57
  • Citations14
12345...
  • References57
  • Citations14
12

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