Cohesive behavior of soft biological adhesives: experiments and modeling

Acta Biomaterialia
Ahmad Khayer DastjerdiFrancois Barthelat

Abstract

Extracellular proteins play a key role in generating and maintaining cohesion and adhesion in biological tissues. These "natural glues" are involved in vital biological processes such as blood clotting, wound healing and maintaining the structural integrity of tissues. Macromolecular assemblies of proteins can be functionally stabilized in a variety of ways in situ that include ionic interactions as well as covalent crosslinking to form protein networks that can extend both within and between tissues. Within tissues, myriad cohesive forces are required to preserve tissue integrity and function, as are additional appropriate adhesive forces at interfaces both within and between tissues of differing composition. While the mechanics of some key structural adhesive proteins have been characterized in tensile experiments at both the macroscopic and single protein levels, the fracture toughness of thin proteinaceous interfaces has never been directly measured. Here, we describe a novel and simple approach to measure the cohesive behavior and toughness of thin layers of proteinaceous adhesives. The test is based on the standard double-cantilever beam test used for engineering adhesives, which was adapted to take into account the high ...Continue Reading

References

Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·W E FowlerH P Erickson
Nov 5, 1999·Biophysical Journal·E A RyanL Lorand
Dec 18, 2001·Journal of Biomedical Materials Research·David H SierraJack E Lemons
Feb 4, 2003·Nature Reviews. Molecular Cell Biology·Laszlo Lorand, Robert M Graham
Jul 19, 2003·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·David M Albala
Dec 2, 2004·Biophysical Chemistry·Harold A Scheraga
May 13, 2005·Nature·Cornelis StormPaul A Janmey
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jean-Philippe ColletJohn W Weisel
Dec 6, 2005·Biophysical Journal·Georg E FantnerPaul K Hansma
Mar 31, 2006·Journal of the American College of Surgeons·David M Albala, Jeffrey H Lawson
Jul 11, 2006·Journal of Biomedical Materials Research. Part a·Miho NakamuraKimihiro Yamashita
Nov 4, 2006·Blood·Glenys A TennentMark B Pepys
Jun 12, 2008·Tissue Engineering. Part B, Reviews·Tamer A E AhmedMax Hincke
Jan 22, 2010·Journal of Thrombosis and Haemostasis : JTH·W LiuM Guthold
Feb 23, 2010·Bone·Philipp J ThurnerTamara Alliston
Feb 23, 2010·PloS One·Paul V AzzopardiGraeme K Hunter
May 21, 2010·Biophysical Journal·Izabela K PiechockaGijsje H Koenderink
Jun 23, 2010·The Journal of Biological Chemistry·Dong Soo HwangJ Herbert Waite
Feb 24, 2011·Acta Biomaterialia·Prashant K PurohitJohn W Weisel
Mar 15, 2011·Journal of the Mechanical Behavior of Biomedical Materials·J A De SouzaB F Sørensen

❮ Previous
Next ❯

Citations

Sep 27, 2013·Journal of the Royal Society, Interface·F Barthelat, M Mirkhalaf
Jan 30, 2014·Nature Communications·M MirkhalafF Barthelat
Oct 23, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Ahmad Khayer DastjerdiFrancois Barthelat
Dec 3, 2014·Journal of the Mechanical Behavior of Biomedical Materials·A Khayer Dastjerdi, F Barthelat
Aug 2, 2017·Periodontology 2000·Jeffrey L EbersoleOctavio A Gonzalez
Apr 25, 2020·Advanced Healthcare Materials·Maryam TavafoghiAli Khademhosseini
Dec 5, 2019·Experimental Mechanics·J D BoydM E Grady
Nov 15, 2018·Micromachines·Zhaozheng Yu, Huanyu Cheng
Jul 29, 2017·Science·J LiD J Mooney
May 11, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Maryam S HosseiniPablo D Zavattieri
May 7, 2021·Advanced Materials·Zhenwei MaJianyu Li
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiqiang JiangLihui Yao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.