Cohort profile - MSK radiation workers: a feasibility study to establish a deceased worker sub-cohort as part of a multicenter medical radiation worker component in the million person study of Low-Dose radiation health effects

International Journal of Radiation Biology
Lawrence DauerJonine Bernstein

Abstract

The National Council on Radiation Protection and Measurements (NCRP) is coordinating an expansive epidemiologic effort entitled the Million Person Study of Low-Dose Radiation Health Effects (MPS). Medical workers constitute the largest occupational radiation-exposed group whose doses are typically received gradually over time. A unique opportunity exists to establish an Institutional Review Board/Privacy Board (IRB/PB) approved, retrospective feasibility sub-cohort of diseased Memorial Sloan Kettering Cancer Center (MSK) medical radiation workers to reconstruct occupational/work history, estimate organ-specific radiation absorbed doses, and review existing publicly available records for mortality from cancer (including leukemia) and other diseases. Special emphasis will be placed on dose reconstruction approaches as a means to provide valid organ dose estimates that are as accurate and precise as possible based on the available data, and to allow proper evaluation of accompanying uncertainties. Such a study that includes validated dose measurements and information on radiation exposure conditions would significantly reduce dose uncertainties and provided greatly improved information on chronic low-dose risks. The feasibility su...Continue Reading

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Citations

Dec 19, 2018·International Journal of Radiation Biology·Richard W LeggettMichael Bellamy
Oct 6, 2020·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Richard W Harbron, Elisa Pasqual
Oct 7, 2021·International Journal of Radiation Biology·John D BoiceRichard Wakeford
Nov 4, 2021·International Journal of Radiation Biology·John D BoiceLawrence T Dauer

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