Cohort profile: design and methods in the eye and vision consortium of UK Biobank.

BMJ Open
Sharon Yu Lin ChuaUK Biobank Eye & Vision Consortium

Abstract

To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction a...Continue Reading

Citations

Sep 3, 2019·Current Eye Research·Tasneem Z Khatib, Keith R Martin
May 20, 2020·Investigative Ophthalmology & Visual Science·Sharon Y L ChuaUNKNOWN UK Biobank Eye and Vision Consortium
Jul 30, 2020·Obesity·Robyn J TappUNKNOWN UK Biobank Eye, Vision Consortium
Nov 26, 2019·Investigative Ophthalmology & Visual Science·Sharon Y L ChuaUNKNOWN UK Biobank Eye and Vision Consortium
Jan 25, 2020·Journal of Ophthalmology·Michele LanzaClaudio Napoli
Apr 1, 2020·Molecular Genetics and Genomics : MGG·Alfred PozarickijUNKNOWN and the UK Biobank Eye and Vision Consortium
Dec 1, 2020·Brain : a Journal of Neurology·Axel PetzoldUNKNOWN UK Biobank Eye and Vision Consortium
Jan 27, 2021·The British Journal of Ophthalmology·Sharon Y L ChuaUNKNOWN UK Biobank Eye and Vision Consortium
Feb 17, 2021·Investigative Ophthalmology & Visual Science·Karina PatasovaPirro G Hysi
Jul 16, 2021·Current Opinion in Ophthalmology·Edward KorotPearse A Keane
Aug 26, 2021·American Journal of Ophthalmology·Zhuoting ZhuMingguang He
Oct 29, 2021·Translational Vision Science & Technology·Denis PlotnikovUNKNOWN UK Biobank Eye and Vision Consortium
Nov 1, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Thomas J LittlejohnsElżbieta Kuźma
Dec 8, 2021·Investigative Ophthalmology & Visual Science·Sharon Y L ChuaPaul J Foster

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Methods Mentioned

BETA
genotyping
X-ray

Software Mentioned

WACMAN
OpenEyes
STATA
Medisoft Ophthalmology

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