Cohort Profile: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS)

Inflammatory Intestinal Diseases
Ekaterina SafroneevaSwiss EoE Cohort Study Group

Abstract

The prospective, observational Swiss Eosinophilic Esophagitis Cohort Study (SEECS) was set up in 2015 with the following goals in mind: (1) to provide up-to-date epidemiologic data; (2) to assess the appropriateness of care; (3) to evaluate the psychosocial impact; and (4) to foster translational research projects. Data capture relies on validated instruments to assess disease activity and focuses on epidemiologic variables and biosamples (esophageal biopsies and blood specimens). An annual inclusion of 70 new patients with eosinophilic esophagitis (EoE) or proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is intended. We herein describe the SEECS cohort profile. The SEECS includes adult patients (age ≥18 years) with EoE or PPI-REE diagnosed according to published criteria. After inclusion, the patients are typically seen once a year for a clinical and endoscopic/histologic follow-up examination. Data are captured using validated questionnaires. Biosamples from patients with gastroesophageal reflux disease (GERD) and controls with a healthy esophagus are collected as well. From January 2016 to July 2017, a total of 111 patients with EoE and 10 patients with PPI-REE were recruited. In addition, esophageal biopsi...Continue Reading

Citations

Jan 29, 2019·International Journal of Epidemiology·Valérie PittetUNKNOWN Swiss IBD Cohort Study Group
May 16, 2018·Annals of the New York Academy of Sciences·Alain SchoepferRoberto Penagini
Dec 23, 2019·International Archives of Allergy and Immunology·Ekaterina SafroneevaAlain M Schoepfer
Nov 20, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Philipp SchreinerLuc Biedermann

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