Cohypermethylation of p16 and FHIT promoters as a prognostic factor of recurrence in surgically resected stage I non-small cell lung cancer

Cancer Research
Jin Seuk KimDuk-Hwan Kim

Abstract

Despite advances in the detection and treatment of lung cancer, the prognosis for patients with lung cancer is poor, partly as a result of recurrences. We retrospectively analyzed the relationship between recurrence and survival in patients with non-small cell lung cancers (NSCLC), and the promoter methylation of p16, GSTP1, FHIT, H-cadherin, and RARbeta2 genes to identify a prognostic molecular marker associated with the recurrence of NSCLC. Methylation status from 335 paraffin blocks was determined by methylation-specific PCR. Of the 335 NSCLC samples, promoter methylation was detected in 35% for p16, 39% for RARbeta2, 42% for H-cadherin, 7% for GSTP1, and 21% for FHIT. Recurrence was observed in 39% (132 of 335) of the patients. Recurrence was significantly associated with histology (P = 0.001) and pathologic stage (P = 0.009). Hypermethylation of any single gene was not associated with recurrence in patients. However, cohypermethylation of p16 and FHIT genes in stage I NSCLCs was associated with an increased risk of recurrence [odds ratio, 6.43; 95% confidence interval (CI), 1.04-20.19; P = 0.02] and poor recurrence-free survival after surgery (hazard ratio, 2.03; 95% CI, 1.09-6.23; P = 0.02). In addition, their survival af...Continue Reading

References

Feb 1, 1990·The Annals of Thoracic Surgery·P Thomas, L Rubinstein
Jan 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·N MartiniR J Ginsberg
Nov 18, 1994·Cell·C J Sherr
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·S A BelinskyJ G Herman
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·L SardG Sozzi
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·L Y FongK Huebner
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M KerstingM Schuermann
Mar 13, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ottavio RenaEnrico Ruffini
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Luca RozGabriella Sozzi
Oct 29, 2002·The Oncologist·Sabine Zöchbauer-MüllerAdi F Gazdar
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Morihito OkadaNoriaki Tsubota
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Sabine Zöchbauer-MüllerAdi F Gazdar
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hojoong KimDuk-Hwan Kim
Sep 25, 2004·Journal of Cellular Physiology·Baocheng HuYa Wang
Oct 21, 2004·British Journal of Cancer·M OtteyK Huebner
Aug 5, 2005·The Oncologist·Boudewijn J M BraakhuisC René Leemans

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Citations

Jun 29, 2010·Surgery Today·Makoto Suzuki, Ichiro Yoshino
Jun 29, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anastasia A PonomaryovaPavel P Laktionov
Sep 26, 2008·The New England Journal of Medicine·Roy S HerbstScott M Lippman
Jun 29, 2007·Journal of Lower Genital Tract Disease·Adhemar Longatto-FilhoAdauto Castelo
May 31, 2007·Current Opinion in Pulmonary Medicine·Alissa K Greenberg, M Sung Lee
Jun 4, 2011·Molekuliarnaia biologiia·A A PonomarevaV V Vlasov
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·David OstWilliam N Rom
Dec 20, 2008·American Journal of Respiratory and Critical Care Medicine·Carla VerriUNKNOWN EUELC Consortium
Mar 20, 2012·BMC Veterinary Research·Maria StrazzulloGiuseppe Borzacchiello
Sep 28, 2007·Annals of Surgical Oncology·Dianliang ZhangChunbao Guo
Oct 25, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L LiK Tian
Mar 19, 2014·Cell Biochemistry and Biophysics·Haixiang YuHua Xin
Dec 19, 2015·Experimental and Molecular Pathology·Hongxiang FengDeruo Liu
Apr 18, 2012·Biochimica Et Biophysica Acta·David S Schrump
Apr 27, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eunkyung KoDuk-Hwan Kim
Jun 19, 2012·Clinical Epigenetics·Semra Demokan, Nejat Dalay
Nov 8, 2011·Clinics in Chest Medicine·Jill E Larsen, John D Minna
Feb 12, 2013·Translational Oncology·Alice PasiniDaniele Calistri
Jul 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Naoki YanagawaTeiichi Motoyama
Mar 21, 2007·Cancer Treatment Reviews·Michalis V KaramouzisAthanasios G Papavassiliou
Oct 1, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Fang Lu, Hong-Tao Zhang
Apr 2, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Scott M LangevinKarl T Kelsey
Oct 1, 2008·BMB Reports·Hye-Jin Sung, Je-Yoel Cho
Nov 26, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yuan ChenIver Petersen
Aug 9, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yujin KimDuk-Hwan Kim
Oct 2, 2009·International Journal of Cancer. Journal International Du Cancer·Lela BuckinghamJohn Coon
May 5, 2009·Expert Opinion on Therapeutic Targets·Rayleen V BowmanKwun M Fong
Aug 31, 2016·International Journal of Oncology·Karolina H CzarneckaEwa Brzeziańska-Lasota

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