CoI -Catalyzed Barbier Reactions of Aromatic Halides with Aromatic Aldehydes and Imines

Chemistry : a European Journal
Marc PressetErwan Le Gall

Abstract

The reductive Barbier coupling of aromatic halides and electrophiles has been achieved using a CoBr2 /1,10-phenanthroline catalytic system and over stoichiometric amounts of zinc. The reaction displayed a broad scope of substrates, including (hetero)aryl chlorides as pro-nucleophiles and aldehydes or imines as electrophiles, leading to diarylmethanols and diarylmethylamines in moderate to excellent yields, respectively.

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Citations

Sep 4, 2021·Journal of the American Chemical Society·Eric S IsbrandtStephen G Newman
Nov 11, 2021·The Journal of Organic Chemistry·Maxwell D ConeyJason B Harper

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