Abstract
Recently, in patients with normal tension glaucoma (NTG) elevated levels of antiphosphatidylserine antibodies (APSA), a subgroup of antiphospholipid antibodies (APLA) were found. Progressive sensorineural hearing loss (PSHL) is associated with autoimmune diseases and also the presence of APLA. To investigate a possible association between NTG and PSHL, 34 patients (age range 31-81 years) with NTG were evaluated for evidence of audiovestibular disorders. Besides ophthalmological standard examinations (slit lamp, IOP, funduscopy, perimetry) scanning laser tomography and polarimetry were performed. From all patients' audiograms, stapedial thresholds and otoacoustic emissions were obtained. The serological testing of patients and controls (40 healthy blood donors older than 50 years) concerned IgG and IgM levels of antibodies against phosphatidylserine (APSA) and beta2 glycoprotein. 23 of 34 NTG patients had hearing loss (PSHL n = 11; presbyacusis n = 12). The NTG patients had significantly higher APSA levels than controls. Elevated APSA concentrations were significantly more frequent in patients with NTG and hearing loss compared with NTG patients with normacusis. These findings show that NTG and hearing loss have a high coinciden...Continue Reading
References
Mar 1, 1992·International Ophthalmology·P F HoyngJ Stilma
Jan 1, 1989·Audiology : Official Organ of the International Society of Audiology·E LaurikainenJ Kallinen
Mar 1, 1988·The Laryngoscope·G B HughesN J Nalepa
Jun 1, 1973·Archives of Ophthalmology·S M DranceF Feldman
Jun 1, 1994·Obstetrical & Gynecological Survey·C J Lockwood, J H Rand
Jul 1, 1993·American Journal of Otolaryngology·K HisashiH Tsuda
Mar 15, 1997·Annals of Internal Medicine·B TumiatiA Parmeggiani
Apr 1, 1997·Ophthalmology·C O'BrienP Detkova
Feb 19, 1998·American Journal of Ophthalmology·M B WaxC Romano
Jun 25, 1998·Deutsche medizinische Wochenschrift·A Eichhorn, W Kirch
Nov 14, 1998·Lupus·E M BeversR F Zwaal
Jul 17, 1999·Archives of Ophthalmology·G TezelM B Wax
Jul 23, 1999·Survey of Ophthalmology·S S Hayreh
Jun 10, 2000·Current Opinion in Ophthalmology·G Tomita
Jun 10, 2000·Current Opinion in Ophthalmology·M B Wax
Sep 1, 2001·Clinical and Experimental Immunology·S KremmerH Grosse-Wilde
Aug 2, 2002·Progress in Retinal and Eye Research·Josef FlammerEinar Stefánsson
Citations
Mar 22, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M Pache
Feb 26, 2005·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Edgar BachorSaid Seidahmadi
Oct 12, 2011·International Journal of Audiology·Gary RanceJonathan Crowston
Jan 12, 2008·Ophthalmology·Shahin YazdaniAli-Reza Faghihi
May 19, 2012·Clinical & Experimental Ophthalmology·Fleur O'HareJonathan G Crowston
Apr 29, 2006·Survey of Ophthalmology·Mona Pache, Josef Flammer
Sep 24, 2013·Progress in Retinal and Eye Research·Sarah F JanssenArthur A B Bergen
Apr 30, 2016·The American Journal of Medicine·Antonio GrecoMarco de Vincentiis
Aug 1, 2016·Immunologic Research·Maria Ida RizzoMarco de Vincentiis
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Vassiliki P PaliobeiAnastasios G P Konstas
Mar 23, 2011·Journal of Glaucoma·Ozgul AltintasYusuf Caglar
Aug 30, 2014·International Ophthalmology Clinics·Daniel I BettisBarbara M Wirostko
Jan 15, 2020·Current Eye Research·Joon Mo KimNa Rae Kim
Aug 21, 2020·Lupus·Adriana M de M FrancoFlavio Signorelli
Nov 9, 2015·Acta Ophthalmologica·Geir TryggvasonHannes Petersen
Jul 25, 2019·Journal of Clinical Medicine·Joon Mo KimOn Behalf Of The Epidemiologic Survey Committee Of The Korean Ophthalmological Society
Aug 4, 2021·Eye·Dl JingW Wang