PMID: 9435915Nov 1, 1994Paper

Coincident plasma ACTH and corticosterone time series: comparisons between young and old rats

Experimental Gerontology
M CarnesR Jaeckels

Abstract

Senescence is accompanied by a reduced ability to respond to a variety of physical and behavioral stressors. A sizable literature has been devoted to the interplay between hypothalamic-pituitary-adrenocortical axis dysfunction and senescence; yet, the precise interactions remain an enigma. Adrenocorticotropic hormone (ACTH) is secreted in pulsatile bursts generating complex signals in the plasma compartment that must be "read" by adrenocortical cells in order to initiate appropriate secretory responses. We have previously demonstrated subtle differences between young and old rats in the pattern of fluctuations in plasma ACTH concentrations over time, despite no difference in mean levels. The present work addressed the physiological significance of these differences in the plasma ACTH signal by analyzing the corresponding plasma corticosterone concentration time series and the relationship between these two hormones over time. Time series of integrated 10-min ACTH and corticosterone concentrations were collected over 4 h at the time of diurnal activation and analyzed in the time and frequency domains. The time of onset of the diurnal surge occurred 20 min later in old rats, and the ratio of corticosterone to ACTH was less at the...Continue Reading

References

May 5, 1975·Biochemical and Biophysical Research Communications·G W BrittonR C Adelman
Jan 22, 1990·Molecular and Cellular Endocrinology·J Schwartz
Jul 1, 1990·The Journal of Endocrinology·B G Charlton
Nov 1, 1990·Medical & Biological Engineering & Computing·R E Challis, R I Kitney
Jan 1, 1988·Gerontology·N S VerkhratskyL I Kharazi
Feb 1, 1986·Neurology·R J Elble
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·B ShermanB Pfohl
Jan 1, 1980·European Journal of Applied Physiology and Occupational Physiology·M FolleniusB Reinhardt
Mar 1, 1983·Journal of Gerontology·S Malamed, R V Carsia
Mar 1, 1984·The Journal of Clinical Endocrinology and Metabolism·H L FehmK H Voigt
Jan 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·V W HylkaJ Meites
Jan 1, 1984·Endocrine Reviews·M E Keller-Wood, M F Dallman
Jan 1, 1983·Experimental Gerontology·R M SapolskyB S McEwen
Mar 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·P M Wise
Aug 1, 1993·Cellular and Molecular Neurobiology·J P Herman
Mar 1, 1993·Experimental Gerontology·P E KloedenO E Rössler

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Citations

May 22, 2002·Mechanisms of Ageing and Development·Rajeshwari MedicherlaSalman Azhar
Mar 17, 2000·Free Radical Biology & Medicine·R Liu, J Choi
Jun 13, 2002·European Journal of Clinical Investigation·A AudigéB Vogt
Feb 1, 1997·Biological Psychiatry·A Gudmundsson, M Carnes
Jul 15, 2015·Statistics in Medicine·Ziyue Liu, Wensheng Guo
Aug 3, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Johanna C van den BeukelAxel P N Themmen

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