PMID: 9181644Jan 1, 1997Paper

Coinfection and superinfection of hepatitis B virus in patients infected with human immunodeficiency virus: no evidence of faster progression to AIDS

Scandinavian Journal of Infectious Diseases
A SiniccoP Gioannini

Abstract

The influence of hepatitis B virus (HBV) on the natural history of human immunodeficiency virus (HIV) infection was evaluated in a prospective study of 347 HIV-positive, AIDS-free individuals infected through injecting drug use and sex and with known seroconversion dates. End points were CD4+ cell count < 200 x 10(6) cell/L and AIDS diagnosis. At entry, 229 had seromarkers to HBV; during the study, 107 had a CD4+ cell count < 200 x 10(6) cells/L and 66 developed AIDS. HBsAg chronic carriers, HBV infection-free subjects and those with baseline evidence of prior HBV infection did not differ in rates of progression to end points. Sexual transmission of HIV was significant predictor of CD4+ cell decline to < 200 x 10(6) cells/l [Hazard ratio (HZ): 1.56, 95% confidence interval (CI): 1.06-2.29, p = 0.0232] and progression to AIDS (HZ: 1.91, CI: 1.17-3.11, p = 0.0091). 15 HIV-positive and HBV infection-free patients had HBV seroconversion. They did not differ from those who remained HBV infection-free in rates of progression to end points, but 40% of them became HBsAg chronic carriers. These results suggest that HBV has no influence on progression of HIV disease, but that patients who have HIV before their HBV infection are more like...Continue Reading

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References

May 1, 1992·Seminars in Liver Disease·A N McNairH C Thomas
Nov 15, 1992·Annals of Internal Medicine·B F ScharschmidtM M Thaler
Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B A KoblinC E Stevens
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J S TwuW S Robinson
Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D J SchneidermanT E Weber
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E ZocchiA De Flora
Jul 15, 1988·Annals of Internal Medicine·A C CollierH H Handsfield
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E SetoJ H Ou
Jan 1, 1986·Journal of Hepatology·S C GordonE R Schiff
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E LebovicsP W Radensky
Feb 1, 1993·The Journal of Infectious Diseases·S J TwuJ Phair

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Citations

Apr 25, 2003·Mathematical Biosciences·Joan SaldañaRicard V Solé
Jun 7, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M StanojevicL J Markovic
Feb 22, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L M M WoltersR A de Man
Oct 29, 2010·Nature Communications·Kuan-Hsiang G HuangPaul Klenerman
Sep 27, 2003·HIV Medicine·M G BrookUNKNOWN British HIV Association
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wang-Huei ShengShan-Chwen Chang
Dec 8, 2011·The Journal of Infectious Diseases·Helen M ChunUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
Oct 13, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·G ChêneF Dabis
Feb 16, 2007·AIDS·Hassane Izzedine, Gilbert Deray
Nov 9, 2004·International Journal of Clinical Practice·M Danta, G Dusheiko
Aug 26, 2014·Infectious Disease Clinics of North America·Lindsay A PettyDonald M Jensen
Aug 2, 2001·Reviews in Medical Virology·E Herrero Martínez
Jul 16, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ralf Otto-KnappThomas Weitzel
Jul 1, 2014·The Journal of Infection·Fred Stephen SarfoDavid R Chadwick
Mar 17, 2007·International Journal of STD & AIDS·R J BurnettM J Mphahlele
May 16, 2000·The American Journal of Gastroenterology·M L Rodríguez-MéndezE Barrio
Aug 2, 2017·PloS One·Lúcia Mabalane ChambalFrancisco Antunes
Apr 4, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Helen M ChunUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
Nov 10, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Faydra I LieveldJoop E Arends
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·R J BurnettM J Mphahlele
Jun 14, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Giulia MorsicaCaterina Uberti-Foppa
Jan 1, 2013·Journal of Sexually Transmitted Diseases·Helen M ChunNancy F Crum-Cianflone
Oct 31, 2014·World Journal of Gastroenterology : WJG·Hsin-Yun SunChien-Ching Hung
Dec 14, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Maria Rita de Cassia Costa MonteiroJosé Fernando de Castro Figueiredo

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