PMID: 16501762Feb 28, 2006Paper

Coinfection between hepatitis B virus and malaria: clinical, serologic and immunologic aspects

Revista Da Sociedade Brasileira De Medicina Tropical
Wornei Silva Miranda BragaCarlos Eduardo Tosta

Abstract

The Amazon region is known for a high prevalence of hepatitis B infection, and accounts for more than 90% of malaria cases in Brazil. It has been suggested that the occurrence of coinfections may be important, and may influence the natural history of both diseases. This study evaluated 545 patients with acute malaria, in Coari, Western Brazilian Amazon. 333 (61.1%) presented Plasmodium vivax malaria, 193 (35.4%) Plasmodium falciparum and 19 (3.5%) mixed infections. The HBsAg prevalence was 4.2% and total anti-HBc 49.7%. Patients with HBV serological markers presented no clinical differences than those with malaria only, nor showed any association with classic signs of hepatic disorder. Although showing no statistical significance, HBsAg reactive subjects presented lower parasitic load and higher antibody titers, suggesting the possibility that the immune response in a coinfected individual is differentiated and leads to a variation in the parasite load and antibody production.

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Citations

Jun 1, 2010·Memórias do Instituto Oswaldo Cruz·Marilaine MartinsJansen Fernandes Medeiros
Jun 5, 2014·BioMed Research International·Nathália Santos Serrão de Castro, Marcelo de Oliveira Lima

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