Coinfection with Rickettsia helvetica and Herpes Simplex Virus 2 in a Young Woman with Meningoencephalitis.

Case Reports in Infectious Diseases
Kenneth NilssonCarl Påhlson

Abstract

Herpes virus type 2 DNA was detected by PCR in the cerebrospinal fluid in a young woman presenting with headache, stiff neck and pleocytosis, and serological findings consistent with reactivation. Since she was exposed to ticks, Lyme disease and tick-borne encephalitis were excluded. Further investigation in an ongoing project, using PCR and sequencing of the amplified products, showed the presence of Rickettsia helvetica in the cerebrospinal fluid. The bacteria were also isolated in Vero cell culture, and microimmunofluorescence confirmed the development of antibodies against Rickettsia spp. with predominance of IgM reactivity consistent with recent infection. She was treated with antibiotics and improved rapidly. The patient could easily have been judged to have isolated herpes meningitis. Because Sweden and other European countries are endemic areas for rickettsioses, the paper reaffirms the importance of investigating for the presence of rickettsial infections in endemic areas in cases of meningitis of uncertain aetiology.

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Citations

Sep 11, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A LindblomK Nilsson
Sep 16, 2016·Experimental & Applied Acarology·Joanna StańczakDaria Lewandowska
Oct 5, 2013·Clinical Microbiology Reviews·Philippe ParolaDidier Raoult
Aug 30, 2019·PLoS Neglected Tropical Diseases·Zuzana SekeyováPierre Edouard Fournier
Jun 25, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K NilssonC Påhlson

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Datasets Mentioned

BETA
GU827073
AF123725
U59723

Methods Mentioned

BETA
PCR
electrophoresis
ELISA

Software Mentioned

ClustalW
Blast
BioEdit

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