Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis.

Infection and Immunity
Lindsey E BazzoneMiguel J Stadecker

Abstract

Infection with the trematode helminth Schistosoma mansoni results in a parasite egg-induced, CD4 T-cell-mediated, hepatointestinal granulomatous and fibrosing inflammation that varies greatly in severity, with a higher frequency of milder forms typically occurring in regions where the disease is endemic. One possible explanation for this is that in these regions the degree of inflammation is lessened by widespread concurrent infection with gastrointestinal nematodes. We tested this hypothesis by establishing a murine coinfection model in which mice were infected with the intestinal nematode parasite Heligmosomoides polygyrus prior to infection with S. mansoni. In CBA mice that naturally display a severe form of schistosomiasis, preinfection with H. polygyrus resulted in a marked reduction in schistosome egg-induced hepatic immunopathology, which was associated with significant decreases in the levels of interleukin-17 (IL-17), gamma interferon, tumor necrosis factor alpha, IL-23, IL-6, and IL-1beta and with increases in the levels of IL-4, IL-5, IL-10, and transforming growth factor beta in mesenteric lymph node cells, purified CD4 T cells, and isolated liver granuloma cells. There also were increases in liver Ym1 and forkhead ...Continue Reading

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F UrbanF D Finkelman
Jul 1, 1987·The American Journal of Tropical Medicine and Hygiene·A W CheeverK G Malley
Jun 1, 1996·European Journal of Immunology·M I AraújoE M Carvalho
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P G FallonA N McKenzie
Sep 15, 2000·Infectious Disease Clinics of North America·I BicaM J Stadecker
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·O AnnackerA Bandeira
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·L I RutitzkyM J Stadecker
Jan 5, 2002·The Journal of Infectious Diseases·Amelia Ribeiro de JesusEdgar M Carvalho
Jan 17, 2002·The American Journal of Tropical Medicine and Hygiene·A Zinn-JustinL Abel
Apr 20, 2002·Science·Maria YazdanbakhshRonald van Ree
May 8, 2002·The Journal of Experimental Medicine·M Angela MontesanoW Evan Secor
Sep 7, 2002·The Journal of Biological Chemistry·John S WelchChristopher K Glass
Nov 6, 2002·The Journal of Biological Chemistry·Sudeepta AggarwalAustin L Gurney
Dec 28, 2002·International Immunology·Diane SewellZsuzsa Fabry
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jan 8, 2003·The Journal of Experimental Medicine·Kevin J MaloyFiona Powrie
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 8, 2003·Revista Da Sociedade Brasileira De Medicina Tropical·Ricardo Tristão-SáReynaldo Dietze
May 10, 2003·Trends in Immunology·William C GauseMiguel J Stadecker
Feb 3, 2004·Clinical Reviews in Allergy & Immunology·Maria Yazdanbakhsh, Paolo M Matricardi
Feb 3, 2004·Clinical Reviews in Allergy & Immunology·André CapronMonique Capron
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias HesseThomas A Wynn
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy S McKee, Edward J Pearce
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuji NagayamaBasil Rapoport
Sep 14, 2004·Immunological Reviews·Rick M MaizelsJudith E Allen
Sep 16, 2004·European Journal of Immunology·David E ElliottJoel V Weinstock
Oct 16, 2004·Immunity·Jay K Kolls, Anders Lindén
Oct 16, 2004·Memórias do Instituto Oswaldo Cruz·Anne Camille La FlammeB Thomas Bäckström
Dec 14, 2004·Gut·R W SummersJ V Weinstock
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura I RutitzkyMiguel J Stadecker
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Mar 18, 2005·Parasite Immunology·D W Dunne, E M Riley
May 3, 2005·Nature Reviews. Immunology·David W Dunne, Anne Cooke
May 24, 2005·Infection and Immunity·Zhong SuMary M Stevenson

❮ Previous
Next ❯

Citations

Oct 26, 2012·Seminars in Immunopathology·Bridget M LarkinMiguel J Stadecker
Sep 23, 2009·The Journal of Experimental Medicine·Rick M MaizelsThomas A Wynn
Dec 25, 2008·Annual Review of Immunology·Fernando O MartinezSiamon Gordon
Feb 13, 2010·Journal of Biomedicine & Biotechnology·Emmanuelle Moreau, Alain Chauvin
Oct 15, 2011·PLoS Pathogens·Patrick M SmithMiguel J Stadecker
Sep 26, 2012·Microbes and Infection·Maria V Periago, Jeffrey M Bethony
Jun 29, 2010·International Journal for Parasitology·Taniawati SupaliMaria Yazdanbakhsh
Sep 16, 2010·Immunology·Carmine StolfiGiovanni Monteleone
Nov 20, 2009·Immunology·Ariana Peck, Elizabeth D Mellins
Oct 11, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jan Axtner, Simone Sommer
Aug 8, 2012·Journal of Autoimmunity·Maverick LauMargaret L Hibbs
Aug 31, 2011·Experimental Parasitology·Rick M MaizelsKatherine A Smith
Dec 12, 2013·The Korean Journal of Parasitology·Shin Ae KangHak Sun Yu
Jan 16, 2015·PLoS Neglected Tropical Diseases·Bo WangChao-Ming Xia
Nov 22, 2011·PLoS Neglected Tropical Diseases·Xiaoyun WenChuan Su
Dec 24, 2016·Immunology·Andrew Godkin, Katherine A Smith
May 1, 2009·Mucosal Immunology·P J Cooper
May 3, 2014·Parasitology·Barbara Castro Pimentel FigueiredoSergio Costa Oliveira
Oct 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·James P HewitsonRick M Maizels
May 27, 2021·Molecular Ecology·Kieran A BatesKayla C King

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved