Coingestion of whey protein and casein in a mixed meal: demonstration of a more sustained anabolic effect of casein.

American Journal of Physiology. Endocrinology and Metabolism
Mattias SoopK Sreekumaran Nair

Abstract

When consumed separately, whey protein (WP) is more rapidly absorbed into circulation than casein (Cas), which prompted the concept of rapid and slow dietary protein. It is unclear whether these proteins have similar metabolic fates when coingested as in milk. We determined the rate of appearance across the splanchnic bed and the rate of disappearance across the leg of phenylalanine (Phe) from coingested, intrinsically labeled WP and Cas. Either [¹⁵N]Phe or [¹³C-ring C₆]Phe was infused in lactating cows, and the labeled WP and Cas from their milk were collected. To determine the fate of Phe derived from different protein sources, 18 healthy participants were studied after ingestion of one of the following: 1) [¹⁵N]WP, [¹³C]Cas, and lactose; 2) [¹³C]WP, [¹⁵N]Cas, and lactose; 3) lactose alone. At 80-120 min, the rates of appearance (R(a)) across the splanchnic bed of Phe from WP and Cas were similar [0.068 ± 0.010 vs. 0.070 ± 0.009%/min; not significant (ns)]. At time 220-260 min, Phe appearance from WP had slowed (0.039 ± 0.008%/min, P < 0.05) whereas Phe appearance from Cas was sustained (0.068 ± 0.013%/min). Similarly, accretion rates across the leg of Phe absorbed from WP and Cas were not different at 80-120 min (0.011 ± 0.0...Continue Reading

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Citations

Jul 21, 2012·BMJ Open·Carl HeneghanMatthew Thompson
Jan 25, 2013·The Journal of Nutrition·Paul T ReidyBlake B Rasmussen
Sep 29, 2015·The Journal of Nutrition, Health & Aging·A M MilanC J Mitchell
Dec 17, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Nicholas A BurdLuc J C van Loon
Feb 18, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Andrew M HolwerdaLuc J C van Loon
Mar 3, 2018·Journal of the International Society of Sports Nutrition·Brad Jon Schoenfeld, Alan Albert Aragon
Jan 23, 2016·The Journal of Experimental Biology·William J SmilesDonny M Camera
Jun 6, 2018·American Journal of Physiology. Endocrinology and Metabolism·Antoinette MoranK Sreekumaran Nair
Sep 16, 2017·The Journal of Clinical Endocrinology and Metabolism·Joseph W BealsNicholas A Burd
Oct 7, 2021·The Journal of Clinical Endocrinology and Metabolism·Vinaya SimhaK Sreekumaran Nair

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