Coinoculation with hepatitis B surface and core antigen promotes a Th1 immune response to a multiepitopic protein of HIV-1

Immunology and Cell Biology
Enrique IglesiasJ C Aguilar

Abstract

It has been defined that strong and multispecific cellular immune responses correlate with a better prognosis during the course of chronic diseases. A cross-enhancing effect on the resulting immune response obtained by the coadministration of recombinant hepatitis B virus (HBV) surface and core Ag was recently observed. With the objective of studying the effect of such Ag on the immune response to coinoculated heterologous Ag and vice versa, several formulations containing the recombinant HBV Ag and a multiepitopic protein (CR3) composed by CTL and Th epitopes from HIV-1 were evaluated by s.c. and mucosal administration. Combinations of two and three Ag were evaluated for cellular and humoral immune responses. The results showed that the best Ag combination for nasal immunization was the mixture comprising the CR3 recombinant HIV protein and both HBV Ag. Similarly, it was also the best formulation for s.c. immunization in aluminium phosphate adjuvant. In conclusion, it is possible to induce a Th1 stimulation of the cellular immune response specific for a HIV-based recombinant protein by formulating this Ag with the recombinant HBV Ag.

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Citations

Jan 5, 2007·Viral Immunology·Enrique IglesiasJulio C Aguilar
Feb 13, 2013·ISRN Gastroenterology·Yasuteru KondoTooru Shimosegawa
Nov 28, 2012·Immunology Letters·Darien García-DíazEnrique Iglesias
Jan 14, 2012·International Immunopharmacology·Enrique IglesiasDarien García
Mar 6, 2007·Vaccine·J C Aguilar, E G Rodríguez
Apr 11, 2013·Human Vaccines & Immunotherapeutics·Enrique Iglesias
Jan 22, 2010·PloS One·Daniel Scott-AlgaraMarie-Louise Michel
Nov 3, 2009·Lupus·E IsraeliY Shoenfeld

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