Col11a1 Regulates Bone Microarchitecture during Embryonic Development

Journal of Developmental Biology
Anthony HafezJulia Thom Oxford

Abstract

Collagen XI alpha 1 (Col11a1) is an extracellular matrix molecule required for embryonic development with a role in both nucleating the formation of fibrils and regulating the diameter of heterotypic fibrils during collagen fibrillar assembly. Although found in many different tissues throughout the vertebrate body, Col11a1 plays an essential role in endochondral ossification. To further understand the function of Col11a1 in the process of bone formation, we compared skeletal mineralization in wild-type (WT) mice and Col11a1-deficient mice using X-ray microtomography (micro-CT) and histology. Changes in trabecular bone microstructure were observed and are presented here. Additionally, changes to the periosteal bone collar of developing long bones were observed and resulted in an increase in thickness in the case of Col11a1-deficient mice compared to WT littermates. Vertebral bodies were incompletely formed in the absence of Col11a1. The data demonstrate that Col11a1 depletion results in alteration to newly-formed bone and is consistent with a role for Col11a1 in mineralization. These findings indicate that expression of Col11a1 in the growth plate and perichondrium is essential for trabecular bone and bone collar formation durin...Continue Reading

References

Jan 1, 1989·Connective Tissue Research·S P Bruder, A I Caplan
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Apr 1, 1986·The Journal of Cell Biology·H C BlairS L Teitelbaum
Jun 1, 1986·Teratology·R E SeegmillerJ C Carey
Feb 14, 1980·Nature·P AshK M Townsend
Feb 2, 1995·The New England Journal of Medicine·S C Manolagas, R L Jilka
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M HatoriI M Shapiro
Jan 8, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M YamazakiT A Einhorn
Sep 11, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G B DaviesN P Morris
Oct 24, 1998·Mechanisms of Development·A L DelezoideJ Bonaventure
Nov 3, 1998·Pediatric Radiology·J Spranger
Apr 1, 2000·The Journal of Biological Chemistry·U K BlaschkeP Bruckner
May 23, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·N P MorrisD R Keene
Oct 14, 2000·Annual Review of Cell and Developmental Biology·B R OlsenW Wang
Jun 12, 2002·The American Journal of Pathology·Olena JacenkoZhuliang Tao
Jan 16, 2003·Hearing Research·Yvonne M Szymko-BennettAndrew J Griffith
May 16, 2003·Nature·Henry M Kronenberg
Sep 10, 2003·The Biochemical Journal·Ryan J MedeckJulia Thom Oxford
Sep 17, 2003·Glycoconjugate Journal·Hideto Watanabe, Yoshihiko Yamada
Jul 1, 1950·American Journal of Clinical Pathology·G GOMORI
Feb 5, 2005·Fetal Diagnosis and Therapy·Israel GoldsteinArie Drugan
Jul 4, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mina OkamotoNoriyuki Tsumaki
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·David F Holmes, Karl E Kadler
Aug 9, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Russell J FernandesDavid R Eyre
Feb 19, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Rachel A KahlerJennifer J Westendorf
Aug 27, 2009·Therapeutics and Clinical Risk Management·Angela B Smith, Culley C Carson
Nov 3, 2010·American Journal of Human Genetics·Stuart W TompsonDaniel H Cohn

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Citations

Aug 18, 2016·Wiley Interdisciplinary Reviews. RNA·Douglas F DluzenMichele K Evans
Sep 13, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Derek T HolyoakMarjolein C H van der Meulen
Jul 9, 2020·Cell Biochemistry and Function·Hongchang YangQiang Zhou
Sep 16, 2017·Scientific Reports·Joana CaldeiraMário Barbosa
Sep 14, 2017·Scientific Reports·Sung Ui ShinWoo Kyung Moon
Sep 27, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elizabeth A LawrenceChrissy L Hammond
Oct 4, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M G VogiatziM A Levine
May 18, 2021·Nature Reviews. Materials·Benjamin J BielajewKyriacos A Athanasiou
Sep 17, 2021·BMC Research Notes·Jonathon C ReeckJulia Thom Oxford

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Methods Mentioned

BETA
X-ray
transgenic

Software Mentioned

ImageVis3D
Sky Scan CT Analyzer ( CTAn )
CTAn

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