Colchicine, a microtubule-disassembling drug, in the therapy of cardiovascular diseases

Cell Biology International
George N Chaldakov

Abstract

Colchicum autumnale, from which colchicine has been isolated more than 100 years ago, has been used as a treatment for pain and swelling for thousands of years. It is one of the few drugs known from that time period whose use has survived to modernity. Over the past decades, advances in the knowledge of (i) cytoskeletal microtubules (МТ), and (ii) anti-inflammatory and anti-fibrotic effects of colchicine, a classical MT-disassembling (tubulin-targeting) agent, have led to potential new uses for this very old drug extended beyond acute gouty arthritis and familial Mediterranean fever. Here, in brief, I present the Bulgarian contribution to possible potential of colchicine in the therapy of cardiovascular diseases that has emerged in the early 1970s in the Laboratory of Electron Microscopy, Medical Institute, Varna, Bulgaria, studying the secretory function of vascular smooth muscle cells. From this time onward, low-dose colchicine (0.5-1.0 mg/daily) was increasingly administered orally for therapy of cardiovascular diseases such as acute coronary syndromes, postoperative atrial fibrillation (in cardiac surgery), pericarditis, cardiac hypertrophy-associated heart failure, restenosis after angioplasty, and systemic necrotizing vas...Continue Reading

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Citations

Jun 13, 2020·Frontiers in Physiology·Li-Yen R Hu, Aikaterini Kontrogianni-Konstantopoulos
Aug 27, 2019·Therapeutic Advances in Chronic Disease·Cheng-Xu MaYing-Dong Li
Jan 20, 2021·Heart, Lung & Circulation·Rahul KurupSanjay Patel
May 2, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Thomas F Whayne
Nov 25, 2020·Vascular Pharmacology·Giovanni CimminoPlinio Cirillo
Mar 12, 2021·Internal and Emergency Medicine·Alessandro AndreisGaetano Maria De Ferrari
Sep 14, 2021·Frontiers in Cardiovascular Medicine·Haiming WangRan Zhang

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