Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome

Seminars in Arthritis and Rheumatism
Yonatan Butbul AvielRiva Brik

Abstract

To evaluate the efficacy of colchicine in reducing the frequency of attacks in patients with PFAPA. We conducted a 6-month open label, randomized, controlled study among patients with PFAPA who attend the Pediatric Rheumatology Clinic at the Rambam Medical Center in Israel. A total of 18 patients aged4 -11 years (males:females ratio = 11:7) were randomized into a control group (I, 10 children) and a study group (II, 8 children). Group I was followed for 6 months without any intervention, and group II was initially followed for 3 months and was thereafter treated with colchicine for 3 additional months, according to standard regimen. During the 6-month period of the study the patients and their physician recorded all the episodes of PFAPA in a constructed log. DNA analyses for the 5 common FMF mutations in Israel were performed in 17 out of the 18 patients. The number of episodes during the first 3 months was similar in both groups (group I 3.2 ± 1.5, group II 4.9 ± 2.3; p ≤ 0.12). Group II had significantly less PFAPA attacks in the second period while on colchicine therapy (4.9 ± 2.3 vs. 1.6 ± 1.2; p ≤ 0.01), in opposition to group I, where no difference in the number of attacks was noted between the first and second period of...Continue Reading

References

Jan 1, 1987·The Journal of Pediatrics·G S MarshallA R Lawton
Jul 7, 1999·The Journal of Pediatrics·K T ThomasK M Edwards
Aug 14, 2003·The Journal of Pediatrics·Cécile CazeneuvePhilippe Reinert
Apr 6, 2006·Archives of Disease in Childhood·D TasherI Dalal
Feb 12, 2009·The Pediatric Infectious Disease Journal·Isabel Cristina Ramos Melo SampaioJosé Gonçalo Duque Pereira Monteiro Marques
May 26, 2009·The Journal of Pediatrics·Werner GaravelloRenato Maria Gaini
Jun 17, 2009·Archives of Otolaryngology--head & Neck Surgery·Lorenzo PignataroPasquale Capaccio
Nov 6, 2009·Acta Paediatrica·H M Feder, J C Salazar
Apr 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Silvia StojanovDaniel L Kastner
Sep 26, 2012·The Journal of Allergy and Clinical Immunology·Laeticia KollyMichaël Hofer
Oct 17, 2012·Archives of Otolaryngology--head & Neck Surgery·Greg LicameliFatma Dedeoglu

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Citations

Mar 18, 2016·Current Rheumatology Reports·Katerina TheodoropoulouMichaël Hofer
Jun 29, 2016·Pediatric Rheumatology Online Journal·Federica VanoniMichaël Hofer
Feb 17, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Muhammed GunesSara Sebnem Kilic
Mar 9, 2017·Rheumatology International·Kalpana ManthiramUNKNOWN Childhood Arthritis and Rheumatology Research Alliance (CARRA) PFAPA Subcommittee
Apr 14, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marco CabrasPaolo Giacomo Arduino
Dec 15, 2020·Advances in Therapy·Ludovico Luca SicignanoRaffaele Manna
Feb 27, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Irene LuuLori Broderick
Feb 21, 2021·Autoimmunity Reviews·Albrecht BetrainsSteven Vanderschueren
Jun 8, 2021·Zeitschrift für Rheumatologie·Z BoyadzhievaM Krusche
Aug 26, 2021·World Journal of Otorhinolaryngology - Head and Neck Surgery·Alicia WangGreg R Licameli

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