Colchicine as first-choice therapy for recurrent pericarditis: results of the CORE (COlchicine for REcurrent pericarditis) trial

Archives of Internal Medicine
Massimo ImazioRita Trinchero

Abstract

Colchicine seems to be a good drug for treating recurrences of pericarditis after conventional treatment failure, but no clinical trial has tested the effects of colchicine as first-line drug for the treatment of the first recurrence of pericarditis. A prospective, randomized, open-label design was used to investigate the safety and efficacy of colchicine therapy as adjunct to conventional therapy for the first episode of recurrent pericarditis. Eighty-four consecutive patients with a first episode of recurrent pericarditis were randomly assigned to receive conventional treatment with aspirin alone or conventional treatment plus colchicine (1.0-2.0 mg the first day and then 0.5-1.0 mg/d for 6 months). When aspirin was contraindicated, prednisone (1.0-1.5 mg/kg daily) was given for 1 month and then was gradually tapered. The primary end point was the recurrence rate. Intention-to-treat analyses were performed by treatment group. During 1682 patient-months (mean follow-up, 20 months), treatment with colchicine significantly decreased the recurrence rate (actuarial rates at 18 months were 24.0% vs 50.6%; P = .02; number needed to treat = 4.0; 95% confidence interval 2.5-7.1) and symptom persistence at 72 hours (10% vs 31%; P = .03...Continue Reading

Associated Clinical Trials

Citations

Nov 1, 2007·Future Cardiology·Massimo Imazio, Rita Trinchero
Jan 16, 2014·Current Atherosclerosis Reports·Stefan M NidorfPeter L Thompson
May 5, 2012·Women's Health·Massimo Imazio, Antonio Brucato
Apr 3, 2010·The Open Cardiovascular Medicine Journal·Sahru YükselArmen Yuri Gasparyan
Dec 31, 2010·World Journal of Cardiology·Paul FarandNicholas Tzouannis
Jan 29, 2008·Current Treatment Options in Cardiovascular Medicine·Geoffrey C Clare, Richard W Troughton
Oct 13, 2011·Current Treatment Options in Cardiovascular Medicine·Dina M Sparano, R Parker Ward
Feb 9, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Luca CantariniMassimo Imazio
Dec 17, 2009·Rheumatology International·Pawan HariLuis Afonso
Mar 26, 2011·Rheumatology International·Z Birsin Ozçakar, Fatoş Yalçınkaya
Feb 5, 2009·European Heart Journal·Massimo ImazioYehuda Adler
Sep 2, 2011·Acta chirurgica Iugoslavica·Arsen D RistićBernhard Maisch
Aug 16, 2012·Heart Failure Reviews·Yang Hyun Cho, Hartzell V Schaff
Mar 19, 2013·Heart Failure Reviews·Bernhard Maisch
Aug 4, 2007·Pediatric Cardiology·G WendelinA Beitzke
Oct 7, 2009·Future Cardiology·Massimo ImazioYehuda Adler
Dec 23, 2015·Expert Review of Cardiovascular Therapy·Syed Wamique YusufPatrick T O'Gara
Aug 12, 2015·Nature Reviews. Cardiology·Massimo ImazioFiorenzo Gaita
Sep 3, 2011·American Heart Journal·Massimo ImazioYehuda Adler
Dec 4, 2015·Future Cardiology·Massimo Imazio, Fiorenzo Gaita
Dec 9, 2015·Herz·B Maisch, UNKNOWN European Society of Cardiology
Jan 29, 2008·International Journal of Cardiology·Massimo Imazio, Rita Trinchero
Oct 20, 2006·International Journal of Cardiology·Massimo Imazio, Rita Trinchero
Oct 12, 2012·Pediatric Cardiology·Alessandra ScardapaneLuciana Breda
Mar 24, 2016·Current Cardiology Reports·Alexander FardmanYehuda Adler
Jul 11, 2006·The American Journal of Cardiology·Antonio BrucatoDavid H Spodick
Oct 13, 2016·Hospital Pharmacy·Kristen Bova CampbellLindsey D Burgess
Aug 6, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Nicholas C Schwier
Sep 18, 2015·Frontiers in Plant Science·Ibrahim JantanSyed Nasir Abbas Bukhari
Sep 1, 2015·BMC Cardiovascular Disorders·Subodh VermaJan O Friedrich
Mar 7, 2015·Current Cardiology Reports·Massimo Imazio
Mar 17, 2015·Current Cardiology Reports·Paul C Cremer, Deborah H Kwon
Apr 25, 2016·Current Cardiology Reports·Massimo ImazioPhilippe Charron
Dec 18, 2014·The New England Journal of Medicine·Martin M LeWinter
Jul 6, 2016·Internal and Emergency Medicine·Ming-Xuan WangCi-Bo Huang
Jul 14, 2016·Journal of Community Hospital Internal Medicine Perspectives·Syed Raza ShahShehryar Shaikh
Mar 29, 2011·La Revue de médecine interne·G Geri, P Cacoub
Sep 3, 2013·The New England Journal of Medicine·Massimo ImazioUNKNOWN ICAP Investigators
Mar 30, 2017·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kevin ChenVenu Menon

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