PMID: 11318982Apr 25, 2001Paper

Colchicine for alcoholic and non-alcoholic liver fibrosis or cirrhosis

Liver
A Rambaldi, C Gluud

Abstract

Colchicine is an anti-inflammatory and anti-fibrotic drug. Several randomized clinical trials have addressed the question whether colchicine has any efficacy in patients with alcoholic as well as non-alcoholic fibrosis and cirrhosis. The objectives were to assess the efficacy of colchicine evaluated in randomized trials on mortality, liver related mortality, liver related complications, liver fibrosis markers, liver histology, alcohol consumption, quality of life, and health economics in patients with alcoholic and non-alcoholic fibrosis or cirrhosis. Interventions encompassed peroral colchicine at any dose versus placebo or no intervention. The trials could be double-blind, single-blind or unblinded. The trials could be unpublished or published as an article, an abstract, or a letter, and no language limitations were applied. All analyses were performed according to the intention-to-treat MEDLINE, The Cochrane Controlled Trials Register, The Cochrane Hepato-Biliary Group Controlled Trials Register and full text searches were combined. Combining the results of 14 randomized clinical trials including 1138 patients demonstrated no significant effects of colchicine on mortality (odds ratio (OR): 0.91; 95% confidence interval (CI) ...Continue Reading

References

Jul 1, 1978·Annals of Internal Medicine·D KershenobichM Rojkind
Feb 10, 1975·Biochimica Et Biophysica Acta·M Rojkind, D Kershenobich
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O RiggioE D'Aquilino
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P F Bruning
Aug 1, 1991·Alimentary Pharmacology & Therapeutics·T W Warnes
Apr 1, 1990·Gastroenterology·T SchmidtH Kaess
Sep 1, 1989·Antimicrobial Agents and Chemotherapy·G H RabbaniK Alam
Jun 30, 1988·The New England Journal of Medicine·D KershenobichM Rojkind
Oct 1, 1987·Statistics in Medicine·D L Demets
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B W TrotmanS E Bernstein
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Nov 1, 1971·Arthritis and Rheumatism·E D Harris, S M Krane
Aug 30, 1972·Nature: New Biology·H P Ehrlich, P Bornstein
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L BouwensE Wisse
Aug 1, 1994·Gut·J FletcherR F Harvey
Mar 1, 1994·Gut·N H Dyer
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F HolzingerA F Hofmann
Sep 3, 1998·Seminars in Arthritis and Rheumatism·E Ben-Chetrit, M Levy
Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S C PresnellG J Smith
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T M Buetler
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S C GordonJ C Wilber
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L L KjaergardC Gluud
Nov 1, 2001·The Cochrane Database of Systematic Reviews·A Rambaldi, C Gluud

❮ Previous
Next ❯

Citations

Feb 9, 2006·Pediatric Surgery International·Vahit YukselenOmer Ozutemiz
Jun 20, 2007·Pharmaceutical Research·Yuji Iimuro, David A Brenner
Jun 24, 2009·Clinical Reviews in Allergy & Immunology·Ziv Paz, Yehuda Shoenfeld
Feb 20, 2003·Journal of Hepatology·Stephen F Stewart, Christopher P Day
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Don C Rockey
May 2, 2002·Journal of Gastroenterology and Hepatology·Jacquelyn J Maher
Apr 11, 2002·European Journal of Gastroenterology & Hepatology·Amedeo Lonardo, Paola Loria
Apr 11, 2002·European Journal of Gastroenterology & Hepatology·Helena Cortez-PintoMiguel C Moura
Jun 18, 2010·World Journal of Gastroenterology : WJG·Sergio MuntoniSandro Muntoni
Feb 22, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Xiaojing ZhuShizhong Zheng
Nov 26, 2009·AJR. American Journal of Roentgenology·Kumaresan SandrasegaranAlex M Aisen
Jan 12, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Don C Rockey
Nov 30, 2010·European Journal of Internal Medicine·Giuseppe CoccoStefano Pandolfi
Jun 30, 2009·Gastroentérologie Clinique Et Biologique·A Mallat, S Lotersztajn
Nov 6, 2008·Clinics in Liver Disease·Don C Rockey
Dec 14, 2006·Clinics in Liver Disease·Don C Rockey
Apr 28, 2006·Journal of Viral Hepatitis·A J MuirD C Rockey
Jun 20, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Soo Hyung RyuDong Jin Suh
Jun 6, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A FedericoC Loguercio
Mar 15, 2005·Clinics in Liver Disease·Robert S O'Shea, Arthur J McCullough
Jan 17, 2012·Journal of Hepatology·Elizabeth L Ellis, Derek A Mann
Jun 2, 2016·Journal of Gastroenterology·Hiroshi FukuiTooru Shimosegawa
Mar 2, 2017·Hepatology International·Sandeep Singh SidhuSimran Sidhu
Jul 24, 2002·The American Journal of Gastroenterology·Andrea RambaldiChristian Gluud
Nov 2, 2011·Therapeutic Advances in Gastroenterology·Michal Cohen-Naftaly, Scott L Friedman
Apr 23, 2005·The Cochrane Database of Systematic Reviews·A Rambaldi, C Gluud
Nov 18, 2018·The Journal of Rheumatology·Jung Sun LeeSeokchan Hong
Sep 24, 2005·Pediatric Transplantation·Benjamin L Shneider, Margret S Magid
Jun 28, 2003·Natural Product Reports·Kenneth W Bentley
Mar 27, 2004·Alimentary Pharmacology & Therapeutics·S Tome, M R Lucey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.