Colchicine for recurrent pericarditis (CORP): a randomized trial

Annals of Internal Medicine
Massimo ImazioCORP (COlchicine for Recurrent Pericarditis) Investigators


Recurrence is the most common complication of pericarditis, affecting 10% to 50% of patients. To evaluate the efficacy and safety of colchicine for the secondary prevention of recurrent pericarditis. Prospective, randomized, double-blind, placebo-controlled multicenter trial. ( registration number: NCT00128414) SETTING: 4 general hospitals in urban areas of Italy. 120 patients with a first recurrence of pericarditis. In addition to conventional treatment, patients were randomly assigned to receive either placebo or colchicine, 1.0 to 2.0 mg on the first day followed by a maintenance dose of 0.5 to 1.0 mg/d, for 6 months. The primary study end point was the recurrence rate at 18 months. Secondary end points were symptom persistence at 72 hours, remission rate at 1 week, number of recurrences, time to first recurrence, disease-related hospitalization, cardiac tamponade, and rate of constrictive pericarditis. At 18 months, the recurrence rate was 24% in the colchicine group and 55% in the placebo group (absolute risk reduction, 0.31 [95% CI, 0.13 to 0.46]; relative risk reduction, 0.56 [CI, 0.27 to 0.73]; number needed to treat, 3 [CI, 2 to 7]). Colchicine reduced the persistence of symptoms at 72 hours (absolute...Continue Reading


Mar 7, 2013·Pediatric Cardiology·Marisol Camacho-Lovillo, Ana Méndez-Santos
Mar 21, 2012·Internal and Emergency Medicine·Francesca GianniUNKNOWN Gruppo di Autoformazione Metodologica (GrAM)
Sep 3, 2013·The New England Journal of Medicine·Massimo ImazioUNKNOWN ICAP Investigators
Mar 28, 2012·Current Opinion in Cardiology·Massimo Imazio
May 5, 2012·Women's Health·Massimo Imazio, Antonio Brucato
Dec 24, 2013·The Permanente Journal·Kevin P Masek, Joel T Levis
Apr 30, 2014·Revista Española De Cardiología·Massimo Imazio
Feb 21, 2014·The New England Journal of Medicine·Massimo ImazioYehuda Adler
Sep 23, 2014·Revista Española De Cardiología·Lovely ChhabraDavid H Spodick
Feb 9, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Luca CantariniMassimo Imazio
Aug 3, 2012·Heart Failure Reviews·Petar M SeferovićBernhard Maisch
Dec 23, 2015·Expert Review of Cardiovascular Therapy·Syed Wamique YusufPatrick T O'Gara
Aug 12, 2015·Nature Reviews. Cardiology·Massimo ImazioFiorenzo Gaita
Dec 4, 2015·Future Cardiology·Massimo Imazio, Fiorenzo Gaita
Dec 9, 2015·Herz·B Maisch, UNKNOWN European Society of Cardiology
Oct 12, 2012·Pediatric Cardiology·Alessandra ScardapaneLuciana Breda
Mar 24, 2016·Current Cardiology Reports·Alexander FardmanYehuda Adler
Oct 13, 2016·Hospital Pharmacy·Kristen Bova CampbellLindsey D Burgess
Nov 17, 2015·Critical Care Nursing Clinics of North America·Janet A Kloos
Aug 6, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Nicholas C Schwier
Sep 18, 2015·Frontiers in Plant Science·Ibrahim JantanSyed Nasir Abbas Bukhari
Mar 7, 2015·Current Cardiology Reports·Massimo Imazio
Jul 6, 2016·Internal and Emergency Medicine·Ming-Xuan WangCi-Bo Huang
Sep 1, 2015·BMC Cardiovascular Disorders·Subodh VermaJan O Friedrich
Mar 30, 2017·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kevin ChenVenu Menon
Feb 12, 2017·La Revue de médecine interne·M ImazioF Gaita
Jun 25, 2015·Revista da Associação Médica Brasileira·Márcio ToniniFábio Fernandes
Nov 26, 2016·Journal of the American College of Cardiology·Paul C CremerAllan L Klein
Dec 19, 2016·Progress in Cardiovascular Diseases·Craig R Asher, Allan L Klein
Nov 30, 2016·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·George LazarosDimitrios Tousoulis
Jan 13, 2017·Pharmacotherapy·Nicholas C SchwierMarie L Davies
Dec 14, 2016·Progress in Cardiovascular Diseases·Niraj S DoctorItzhak Kronzon
Aug 29, 2014·The Annals of Pharmacotherapy·Lovely ChhabraDavid H Spodick
May 21, 2014·The Annals of Pharmacotherapy·Sarah E Norrid, Carrie S Oliphant
Dec 1, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·John AgzarianYaron Shargall
Aug 24, 2017·The British Journal of Dermatology·B DasgebD L Sackett
Mar 13, 2018·Current Opinion in Cardiology·Sophie Van Linthout, Carsten Tschöpe
Jan 28, 2016·The Cochrane Database of Systematic Reviews·Lars G HemkensMatthias Briel

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.