Colchicine for stroke prevention in patients with coronary artery disease: a systematic review and meta-analysis.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
A H KatsanosG Tsivgoulis

Abstract

Although clinical trials suggest that colchicine may reduce the risk of vascular events in patients with a history of coronary artery disease, its effect on the prevention of cerebrovascular events still remains unclear. A systematic review and meta-analysis was performed of all available randomized controlled trials (RCTs) reporting on incident strokes during the follow-up of patients with a history of cardiovascular disease randomized to colchicine treatment or control (placebo or usual care). Four RCTs were identified, including a total of 5553 patients (mean age 61 years, 81% males), with a follow-up ranging from 1 to 36 months. Colchicine treatment was associated with a significantly lower risk of incident stroke during follow-up compared to control (risk ratio 0.31, 95% confidence interval 0.13-0.71), without heterogeneity across included studies (I2  = 0%). Based on the pooled incident stroke rate of control groups (0.9%) in the included RCTs, it was estimated that administration of low-dose colchicine to 161 patients with coronary artery disease would prevent one stroke during a follow-up of 23 months. Colchicine treatment decreases stroke risk in patients with a history of coronary artery disease. The effect of colchic...Continue Reading

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Citations

Mar 24, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J S K Chan
Apr 16, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V Caso, J-L Mas
Jul 28, 2020·JAMA Neurology·Aristeidis H Katsanos, Robert G Hart
Jun 9, 2021·Scientific Reports·G J PenningsL Kritharides
Jun 25, 2021·Stroke; a Journal of Cerebral Circulation·Peter J KellyGeorgios Tsivgoulis
Jul 22, 2021·Toxicology Reports·Dimitrios A VrachatisGeorge Giannopoulos
Jul 25, 2021·Journal of Clinical Medicine·Aristeidis H KatsanosGeorgios Tsivgoulis
Sep 25, 2021·Expert Opinion on Investigational Drugs·Apostolos SafourisGeorgios Tsivgoulis

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