COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial

European Heart Journal
Massimo ImazioCOPPS Investigators


No drug has been proven efficacious to prevent the post-pericardiotomy syndrome (PPS), but colchicine seems safe and effective for the treatment and prevention of pericarditis. The aim of the COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS) trial is to test the efficacy and safety of colchicine for the primary prevention of the PPS. The COPPS study is a multicentre, double-blind, randomized trial. On the third post-operative day, 360 patients (mean age 65.7 ± 12.3 years, 66% males), 180 in each treatment arm, were randomized to receive placebo or colchicine (1.0 mg twice daily for the first day followed by a maintenance dose of 0.5 mg twice daily for 1 month in patients ≥70 kg, and halved doses for patients <70 kg or intolerant to the highest dose). The primary efficacy endpoint was the incidence of PPS at 12 months. Secondary endpoint was the combined rate of disease-related hospitalization, cardiac tamponade, constrictive pericarditis, and relapses. Baseline characteristics were well balanced between the study groups. Colchicine significantly reduced the incidence of the PPS at 12 months compared with placebo (respectively, 8.9 vs. 21.1%; P = 0.002; number needed to treat = 8). Colchicine also reduced...Continue Reading


Feb 1, 1991·Seminars in Arthritis and Rheumatism·E Ben-Chetrit, M Levy
Oct 1, 1990·Circulation·J GuindoA Bayés de Luna
Dec 26, 1987·Lancet·A Rodríguez de la SernaA Bayés de Luna
Jan 1, 1994·European Heart Journal·A MillaireG Ducloux
May 1, 1994·The American Journal of Cardiology·Y AdlerY Shoenfeld
Feb 15, 1996·The New England Journal of Medicine·B T Emmerson
Mar 1, 1997·Heart & Lung : the Journal of Critical Care·S E Prince, B A Cunha
Jan 24, 1998·QJM : Monthly Journal of the Association of Physicians·S KeesA Livneh
May 16, 2002·Current Rheumatology Reports·Yair Molad
Aug 17, 2002·Psychoneuroendocrinology·Deborah M Hodgson, Brendon Knott
Feb 8, 2003·Herz·Yaron FinkelsteinYehuda Adler
May 4, 2004·European Heart Journal·Bernhard MaischUNKNOWN Task Force on the Diagnosis and Management of Pricardial Diseases of the European Society of Cardiology
Aug 30, 2005·The American Journal of Cardiology·Massimo ImazioRita Trinchero
Feb 5, 2009·European Heart Journal·Massimo ImazioYehuda Adler
Aug 14, 2009·Expert Review of Cardiovascular Therapy·Massimo ImazioYehuda Adler
Oct 28, 2009·Nature Reviews. Cardiology·Massimo ImazioYehuda Adler
Feb 24, 2010·Circulation·Massimo ImazioYehuda Adler

❮ Previous
Next ❯


Oct 5, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Matthias LenskiMichael Böhm
May 3, 2011·Current Infectious Disease Reports·Massimo Imazio
Apr 11, 2012·Current Opinion in Pulmonary Medicine·Massimo Imazio
Sep 2, 2011·Acta chirurgica Iugoslavica·Arsen D RistićBernhard Maisch
Dec 30, 2014·Indian Journal of Pharmacology·Chintan Trivedi, Mihir Sadadia
Jan 10, 2014·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·J J BrugtsO C Manintveld
Oct 13, 2014·The American Journal of Cardiology·M Chadi AlraiesBalaji K Tamarappoo
Nov 26, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Vladimir V LomivorotovAlexander M Karaskov
Aug 27, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ammar M KilluSamuel J Asirvatham
Dec 26, 2012·The Annals of Thoracic Surgery·Mario GaudinoMassimo Massetti
Aug 14, 2012·Autoimmunity Reviews·Silvia MaestroniAntonio Brucato
Jul 10, 2012·International Journal of Cardiology·Mahboob AlamHani Jneid
Oct 31, 2015·Journal of Cardiovascular Electrophysiology·Sampath GundaDhanunjaya R Lakkireddy
Mar 31, 2012·Medicina clínica·Elena VillamañánMargarita Ruano
Mar 1, 2012·International Journal of Cardiology·Massimo ImazioYehuda Adler
Feb 1, 2012·Current Problems in Cardiology·David M DudzinskiJudy W Hung
Sep 3, 2011·American Heart Journal·Massimo ImazioYehuda Adler
Dec 4, 2015·Future Cardiology·Massimo Imazio, Fiorenzo Gaita
Feb 14, 2013·Clinical Cardiology·Gal MarkelYehuda Adler
Mar 24, 2016·Current Cardiology Reports·Alexander FardmanYehuda Adler
Jun 1, 2011·The American Journal of Cardiology·Massimo ImazioYehuda Adler
Jul 30, 2011·The American Journal of Cardiology·Massimo ImazioYehuda Adler
Feb 18, 2015·Cardiology in Review·Paola CasanovaOrlando Santana
Oct 13, 2016·Hospital Pharmacy·Kristen Bova CampbellLindsey D Burgess
Aug 6, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Nicholas C Schwier
Jan 30, 2015·Pharmacotherapy·Nicholas C SchwierShivdev K Rao
Oct 9, 2013·American Journal of Therapeutics·John StackGeraldine McCarthy
Sep 18, 2015·Frontiers in Plant Science·Ibrahim JantanSyed Nasir Abbas Bukhari
Sep 1, 2015·BMC Cardiovascular Disorders·Subodh VermaJan O Friedrich
Mar 15, 2015·Heart, Lung & Circulation·Jwalant RavalA Robert Denniss
May 27, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Jesse M RaitenJacob T Gutsche
Apr 29, 2015·Atherosclerosis·Razi KhanPhilippe L L'Allier
Feb 24, 2015·The Journal of Thoracic and Cardiovascular Surgery·Joonas LehtoTuomas Kiviniemi
Jan 26, 2016·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler
Mar 19, 2015·The American Journal of Cardiology·Georgios GiannopoulosSpyridon Deftereos
Mar 19, 2013·Journal of the American College of Cardiology·Spyridon DeftereosMichael W Cleman
Mar 7, 2015·Current Cardiology Reports·Massimo Imazio
Oct 9, 2012·International Journal of Cardiology·Massimo Imazio, Brian D Hoit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

© 2022 Meta ULC. All rights reserved