Colchicine protects against hyperoxic lung injury in neonatal rats

Neonatology
Ramazan OzdemirUgur Dilmen

Abstract

Bronchopulmonary dysplasia (BPD) is characterized by inflammation, fibrosis and mucosal necrosis, which leads to emphysematous coalescence of alveoli. We tested whether prophylaxis with colchicine , an anti-inflammatory, antioxidant and antifibrotic drug, would decrease the severity of lung injury in an animal model of BPD. Twenty-five rat pups were divided into three groups: control (n = 8), hyperoxia (n = 7), and hyperoxia + colchicine (n = 10). The hyperoxia groups were exposed to >95% oxygen from day 1 to 10 of life. On day 10, the animals were sacrificed and the lungs were processed for histology and biochemical analysis. Lung morphology was assessed by the mean linear intercept (MLI), a measure of alveolar size. The degree of lung inflammation and antioxidant capacity were assessed by quantifying lung homogenate tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels. Colchicine significantly decreased lung damage as determined by the MLI in the hyperoxia groups (p < 0.01). The median level of lung MDA was significantly higher in the hyperoxia group compared with the control group (p < 0.05) and the colchicine-treated group (p < ...Continue Reading

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Citations

Aug 26, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Mehmet Yekta OncelUgur Dilmen
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ramazan OzdemirAhmet Karadag
Mar 1, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Vineet Bhandari
Mar 8, 2013·The Journal of Surgical Research·Sadik YurttutanUgur Dilmen
Oct 12, 2014·Reproductive Sciences·Raziye Keskin KurtTuncay Delibasi
Jun 5, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Osman BastugSelim Kurtoglu
Aug 25, 2020·Current Pharmacology Reports·Naomi SchlesingerLuigi Brunetti
Dec 3, 2020·PloS One·Jocelyn DupuisJean-Claude Tardif

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