Colchicine reversibly inhibits electrical activity in arthropod mechanoreceptors

Journal of Neurobiology
R Schafer, P D Reagan

Abstract

Colchicine and some other microtubule-active agents inhibit the electrical responses of cockroach tibial spine mechanoreceptors. Lumicolchicine, a colchicine analog which does not bind to microtubule protein, does not inhibit mechanoreceptive responses. Colchicine inhibition of peripheral mechanoreceptive responses is fully reversible and dose dependent, but colchicine has no effect on conduction in leg nerve axons. Colchicine inhibition is therefore an effect on the sensory dendrites or soma. The inhibition produced by colchicine could be produced by several effects. Colchicine may inhibit because it (1) disrupts the numerous intracellular microtubules which are a part of this sensory receptor's dendrite, (2) blocks axoplasmic transport of essential materials to the sensory dendrite, or (3) binds to tubulin or other proteins in the dendritic membrane.

References

Jan 1, 1976·Annual Review of Biophysics and Bioengineering·M L Wiederhold
Mar 15, 1977·Experientia·D Mitolo-Chieppa
Dec 9, 1976·Nature·B Bhattacharyya, J Wolff
Jan 1, 1973·Journal of Theoretical Biology·J Atema
Jan 1, 1974·The Journal of Cell Biology·J Stadler, W W Franke
Jun 1, 1974·Journal of Insect Physiology·E F Block, W J Bell
Oct 1, 1971·The Journal of Cell Biology·H FeitM L Shelanski
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D T Moran, F G Varela
Nov 1, 1969·Journal of Insect Physiology·K M Chapman, T R Nichols
Sep 1, 1970·Journal of Neurochemistry·H Feit, S H Barondes
Jul 1, 1968·The Journal of Cell Biology·S L PalayP M Orkand
Oct 22, 1966·Nature·W M Sams, N V Carroll

❮ Previous
Next ❯

Citations

May 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·A I Esakov, O D Meshcheriakova
Jan 1, 1985·The Journal of Membrane Biology·S Terakawa, T Nakayama
Oct 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J E KusterE J Sanders

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.