PMID: 19912886Oct 1, 1992Paper

Cold- and ethanol-induced hypothermia reduces cellular levels of mRNA-encoding Thyrotropin-Releasing Hormone (TRH) in neurons of the preoptic area

Molecular and Cellular Neurosciences
D H DolanR T Zoeller

Abstract

Thyrotropin-releasing hormone (TRH)-containing neurons have been implicated in the central control of body temperature. TRH-containing neurons are located in brain areas known to influence body temperature, and TRH injected into these areas can produce changes in body temperature. While these lines of evidence support the view that central TRH is involved in thermoregulation, it has been difficult to confirm that TRH-containing neurons of the preoptic area are involved in this process. We used a different approach to test this hypothesis, based on recent evidence that changes in cellular levels of neuropeptide mRNA are linked to changes in neurosecretory processes. Hence, we predicted that if TRH neurons of the preoptic area are involved in body temperature regulation, cellular levels of TRH mRNA would be altered in animals in which body temperature had been experimentally altered. TRH mRNA levels were measured by in situ hybridization histochemistry in neurons of the preoptic area (POA) of animals that had been exposed to cold (5 degrees C) or that had been given a hypothermic dose of ethanol. Cellular levels of TRH mRNA were reduced by both treatments. However, cellular levels of the mRNA-encoding gastrin-releasing peptide we...Continue Reading

References

Dec 1, 1990·British Journal of Pharmacology·K Varga, G Kunos
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Aug 1, 1989·Drug and Alcohol Dependence·B MalinowskaW Buczko
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Citations

Jul 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R T ZoellerF L Moore
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Apr 2, 2014·Nature Reviews. Microbiology·Chris J Paddon, Jay D Keasling

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