Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase.

Biochimica Et Biophysica Acta
Y Cheng, David Hauton

Abstract

The contribution of triacylglycerol to energy provision in the hypertrophied heart, mediated through lipoprotein lipase (LPL) is largely unknown and the contribution of very-low-density lipoprotein (VLDL) receptor to control of LPL presentation at the endothelium is unclear. For isolated perfused rat hearts, cold acclimation (CA) induced volume-overload hypertrophy, with decreased developed pressure (P<0.01), increased end-diastolic volume of the left ventricle (P<0.001) and a loss of contractile reserve in response to dobutamine challenge (P<0.01). Oleate utilisation by perfused hearts was unchanged by CA, however uptake of intralipid emulsion increased 3-fold (P<0.01). CA increased the proportion of lipid deposited in tissue lipids from 10% in euthermic controls to 40% (P<0.01) although the overall contribution of individual lipid classes was unaffected. Cold acclimation significantly increased heparin-releasable LPL (P<0.05) and tissue residual LPL (P<0.01). Western blot analysis indicated preserved expression of proteins coding for SERCA2, muscle-CPT1 and VLDL-receptor following CA, while AMPKalpha2 and phospho-AMPKalpha2 were unaffected. These observations indicate that for physiological hypertrophy AMPK phosphorylation do...Continue Reading

References

Dec 1, 1977·Canadian Journal of Biochemistry·N Bégin-Heick, H M Heick
Jun 1, 1992·Cardiovascular Research·L B TanW A Clark
Jan 1, 1985·Respiration Physiology·S R Kayar, N Banchero
Aug 4, 1994·Biochimica Et Biophysica Acta·G D LopaschukB O Schönekess
Sep 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K D O'BrienA Chait
Mar 13, 1999·American Journal of Hypertension·N I RoukoyatkinaM I Talan
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·N SambandamB Rodrigues
Jan 12, 2002·Kidney International·Tadashi SatoNosratola D Vaziri
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Ayanna S AugustusIra J Goldberg
Dec 5, 2002·American Journal of Physiology. Endocrinology and Metabolism·Laura L AtkinsonGary D Lopaschuk
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Laura L ListenbergerJean E Schaffer
Jul 11, 2003·Journal of the Society for Gynecologic Investigation·Guohu LiLubo Zhang
Jan 1, 1957·The American Journal of Physiology·O HEROUX, J S PIERRE
May 18, 2004·Journal of Lipid Research·Jeltje R GoudriaanPatrick C N Rensen
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saumya SharmaHeinrich Taegtmeyer
Jan 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xinxin YuCai Li
Feb 11, 2005·American Journal of Physiology. Endocrinology and Metabolism·Priya PillutlaIra J Goldberg
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·John P KonhilasLeslie A Leinwand
May 21, 2005·Circulation Research·Mansoureh EghbaliEnrico Stefani
Apr 25, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi XuSandra T Davidge
May 30, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·David HautonStuart Egginton
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Valentina SukoninaGunilla Olivecrona
Jun 28, 2007·American Journal of Physiology. Endocrinology and Metabolism·Gengshu WuThomas Olivecrona
Dec 18, 2007·Sports Medicine·Louise H NaylorDaniel J Green
Feb 12, 2008·Biochemical and Biophysical Research Communications·Yasuo ZenimaruIsamu Miyamori
Apr 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ramesh SaeediMichael F Allard

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Citations

Jan 8, 2009·BMC Cardiovascular Disorders·David Hauton, Victoria Ousley
Jul 21, 2011·Journal of Lipids·You-Guo Niu, Rhys D Evans
Jul 4, 2012·Molecular and Cellular Endocrinology·Jeevan NagendranJason R B Dyck
Jan 7, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Tomoko MatsubaraMiho Hirabayashi
Aug 29, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·David HautonStuart Egginton
Nov 1, 2015·Mayo Clinic Proceedings·Biff F Palmer, Deborah J Clegg
Feb 16, 2010·Metabolism: Clinical and Experimental·David Hauton
Jan 10, 2012·Biochimica Et Biophysica Acta·David Hauton, Germaine M Caldwell
Jun 28, 2013·Adipocyte·Sheila Collins, Marica Bordicchia
Apr 12, 2014·Biochimica Et Biophysica Acta·Sander Kersten
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Luisa A KetzerLeopoldo de Meis
Mar 11, 2017·Orphanet Journal of Rare Diseases·Yan HuangZaza Khuchua
Dec 1, 2020·Frontiers in Physiology·Xue KongWei Ge
Feb 23, 2013·The Journal of Experimental Biology·Stuart EggintonDavid Hauton
Aug 26, 2011·The Journal of Experimental Biology·David HautonStuart Egginton

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Methods Mentioned

BETA
protein assay

Software Mentioned

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ImageJ

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