Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism

Cell Reports
Matthew D LynesYu-Hua Tseng

Abstract

Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure.

References

Jan 1, 1987·The Japanese Journal of Physiology·K OgawaA Kuroshima
Jun 5, 2003·The Journal of Biological Chemistry·Hildur PalsdottirCarola Hunte
Jun 30, 2006·Biochimica Et Biophysica Acta·Barbara CannonJan Nedergaard
Mar 3, 2007·The EMBO Journal·Kyoko Shinzawa-ItohShinya Yoshikawa
Aug 30, 2008·Biochimica Et Biophysica Acta·Amit S JoshiMiriam L Greenberg
Sep 10, 2008·The Journal of Cell Biology·Steven M ClaypoolCarla M Koehler
Apr 10, 2009·The New England Journal of Medicine·Wouter D van Marken LichtenbeltG J Jaap Teule
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Apr 10, 2009·The New England Journal of Medicine·Kirsi A VirtanenPirjo Nuutila
Jan 25, 2011·Nature Medicine·Alexander BarteltJoerg Heeren
May 16, 2012·The Journal of Biological Chemistry·Michael A KiebishRichard W Gross
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aaron M CypessC Ronald Kahn
Aug 17, 2014·Biochimica Et Biophysica Acta·Miriam HoeneRainer Lehmann
Nov 30, 2014·Journal of Bioenergetics and Biomembranes·Cunqi YeMiriam L Greenberg
Mar 11, 2015·Nature Communications·Jimmy F P BerbéePatrick C N Rensen
Jun 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yang LeePaul G Crichton
Oct 23, 2015·Genes & Diseases·Matthew D Lynes, Yu-Hua Tseng
Apr 3, 2016·Lipids·Hannah E RockwellMichael A Kiebish
Apr 20, 2017·Nature Communications·Alexander BarteltJoerg Heeren
Jun 16, 2017·Scientific Reports·Xiyuan LuStefano Tiziani
Aug 2, 2017·Annals of the New York Academy of Sciences·Matthew D Lynes, Yu-Hua Tseng
Jun 5, 2018·Cell Metabolism·Elahu G SustarsicZachary Gerhart-Hines

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Citations

Sep 21, 2018·Antioxidants & Redox Signaling·Maroua FerhatSihem Boudina
Sep 11, 2019·Endocrinology·Matthew D LynesYu-Hua Tseng
Jul 3, 2020·The Journal of Cell Biology·Michelle Grace AcobaSteven M Claypool
Feb 15, 2019·Biology·Carmem Peres Valgas da SilvaKristin I Stanford
Jun 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mengxi JiangNai-Jia Huang
Oct 17, 2019·Nutrients·Diego Hernández-Saavedra, Kristin I Stanford
Nov 20, 2019·Nature Metabolism·Oliver HahnLinda Partridge
Nov 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Danielle WolfsElvira Isganaitis
Aug 20, 2019·Trends in Endocrinology and Metabolism : TEM·Hongsuk ParkIrfan J Lodhi
Jul 28, 2020·Trends in Analytical Chemistry : TRAC·Jianing Wang, Xianlin Han
Nov 12, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gerard PernesGraeme I Lancaster
Mar 7, 2021·Metabolites·Helaina Von BankJudith Simcox
Mar 14, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Sona Rajakumari, Simran Srivastava
Mar 17, 2021·Scientific Reports·Ntsiki M HeldMichel van Weeghel
Sep 24, 2020·Journal of Pharmaceutical and Biomedical Analysis·Katarzyna MiniewskaMichal Ciborowski
May 1, 2021·International Journal of Molecular Sciences·Norma DahdahPablo Miguel Garcia-Roves
Jul 25, 2021·International Journal of Molecular Sciences·Lowell DilworthFelix Omoruyi
Jul 12, 2021·Molecular and Cellular Endocrinology·Lorna MulveyColin Selman
Jul 31, 2021·Nature Reviews. Endocrinology·Christopher Auger, Shingo Kajimura

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