Cold-adapted Antarctic fish: the discovery of neuroglobin in the dominant suborder Notothenioidei

Gene
C-H Christina ChengCinzia Verde

Abstract

Novel globins, such as neuroglobin (Ngb) and cytoglobin, have recently been discovered in many vertebrates. Ngb is mainly expressed in neurons and plays a neuroprotective role during hypoxic stress. Neuronal hypoxia and cerebral ischemia induce Ngb expression; knocking down Ngb expression increases hypoxic neuronal injury in vitro and ischemic cerebral injury in vivo. Although Ngb was originally identified in mammals, it is also present in fish, including the zebrafish Danio rerio. We have discovered the Ngb gene to be present in red-blooded notothenioid fish species, and in at least 13 of the 16 species of the white-blooded icefish family Channichthyidae. The deduced amino-acid sequences are well conserved. The retention of the Ngb gene by channichthyids, despite the loss of hemoglobin and myoglobin, appears very intriguing.

References

Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·L ChenC H Cheng
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·L LiuJ S Stamler
Sep 14, 2001·Biochemical and Biophysical Research Communications·C AweniusT Burmester
Nov 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Beatrice ValloneG Ulrich Nienhaus
May 3, 2006·The Journal of Experimental Biology·Bruce D Sidell, Kristin M O'Brien
Jul 28, 2006·Molecular Biology and Evolution·Thomas J NearH William Detrich
Jun 8, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C-H Christina Cheng, H William Detrich
Oct 19, 2007·Current Opinion in Pharmacology·David A GreenbergAdil A Khan
Apr 18, 2008·Biochemistry·Seiji Watanabe, Keisuke Wakasugi

❮ Previous
Next ❯

Citations

May 15, 2012·Marine Genomics·Daniela GiordanoCinzia Verde
Nov 9, 2016·Molecular Aspects of Medicine·Paolo AscenziMaria Marino
Feb 16, 2019·The Journal of Experimental Biology·Kevin T BilykC-H Christina Cheng
Feb 26, 2019·Nature Ecology & Evolution·Bo-Mi KimHyun Park
Dec 1, 2020·Marine Genomics·Daniela GiordanoCinzia Verde

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.