Cold Agglutinins in Peripheral Blood with Atypical Cells with an Owl-Eye Appearance in Bone Trephine

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Ayesha Majeed Memon, Farheen Karim

Abstract

Autoimmune hemolytic anemia (AIHA) is a form of hemolytic anemia in which red cells lysis occurs due to presence of an autoantibody. Association of AIHA is well known with lymphoproliferative disorders, especially with non-Hodgkin's lymphoma. However, AIHA in association with Hodgkin's lymphoma is seen occasionally. Of the AIHA associated with Hodgkin's lymphoma, most are of warm type or mixed type. Cold AIHA, as seen in our case, is very rare in Hodgkin's lymphoma.

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