Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell.

Rheumatology International
Cheng LuAiping Lu

Abstract

The research is aimed to explore the distinct molecular signatures in discriminating the rheumatoid arthritis patients with traditional Chinese medicine (TCM) cold pattern and heat pattern. Twenty patients with typical TCM cold pattern and heat pattern were included. Microarray technology was used to reveal gene expression profiles in CD4+ T cells. The signal intensity of each expressed gene was globally normalized using the R statistics program. The ratio of cold pattern to heat pattern in patients with RA at more or less than 1:2 was taken as the differential gene expression criteria. Protein-protein interaction information for these genes from databases was searched, and the highly connected regions were detected by IPCA algorithm. The significant pathways were extracted from these subnetworks by Biological Network Gene Ontology tool. Twenty-nine genes differentially regulated between cold pattern and heat pattern were found. Among them, 7 genes were expressed significantly more in cold pattern. Biological network of protein-protein interaction information for these significant genes were searched and four highly connected regions were detected by IPCA algorithm to infer significant complexes or pathways in the biological ne...Continue Reading

References

Jan 1, 1990·Epidemiologic Reviews·M C Hochberg, T D Spector
Jan 1, 1993·Autoimmunity·A A PostigoF Sánchez-Madrid
Dec 4, 1998·Springer Seminars in Immunopathology·N Oppenheimer-Marks, P E Lipsky
Sep 1, 1999·Clinical Rheumatology·P P Sfikakis, M Mavrikakis
Nov 28, 2002·Nature Genetics·Gary A Churchill
Jun 18, 2003·Current Opinion in Pharmacology·Hongtao Liu, Richard M Pope
Jun 29, 2004·World Journal of Gastroenterology : WJG·Ai-Ping LuQing-Ping Lu
Mar 4, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Shinya KobayashiTakashi Okamoto
Jul 8, 2005·Applied Bioinformatics·Naomi Altman
Sep 28, 2005·Trends in Pharmacological Sciences·Wen-Yue Jiang
Jan 12, 2007·Endocrine, Metabolic & Immune Disorders Drug Targets·Takashi Okamoto
Feb 3, 2007·Trends in Molecular Medicine·Riina M Luik, Richard S Lewis
Dec 7, 2007·Cancer Biology & Therapy·Hideo SakamotoBo R Rueda
Jan 11, 2008·American Journal of Physiology. Cell Physiology·Dan ShanJohn C Chatham
Mar 12, 2008·Apoptosis : an International Journal on Programmed Cell Death·Shaun Rosebeck, Douglas W Leaman
Jul 16, 2008·Journal of Hepatology·Ileana AdercaLewis R Roberts
Nov 26, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Marie-Christophe BoissierNatacha Bessis
Dec 18, 2008·Nature Immunology·Monika Vig, Jean-Pierre Kinet
Feb 24, 2009·Arthritis Research & Therapy·Lisa G M van BaarsenCornelis L Verweij
Apr 21, 2009·Methods in Molecular Biology·Fabia BrentanoSteffen Gay
May 29, 2009·Pharmacological Reviews·Luke A J O'NeillSarah L Doyle
Sep 17, 2009·Immunological Reviews·Masatsugu Oh-hora
Sep 18, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Cheng LuAiping Lu
Sep 24, 2009·Current Rheumatology Reports·Qi-Quan Huang, Richard M Pope
Oct 27, 2009·BMC Bioinformatics·Alejandro Real-ChicharroJosé F Aldana-Montes
Oct 20, 2009·Arthritis Research & Therapy·William J McCormackLuke A O'Neill
Dec 17, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Herman van WietmarschenJan van der Greef

❮ Previous
Next ❯

Citations

Nov 8, 2011·Chinese Journal of Integrative Medicine·Ai-Ping Lu, Ke-Ji Chen
Oct 22, 2013·Trends in Pharmacological Sciences·Xuan LiuDe-An Guo
Apr 5, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Zhongjie ZouShengwang Liang
Sep 4, 2014·Chinese Journal of Integrative Medicine·Chi ZhangAi-Ping Lu
Jun 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Jianye DaiYongyu Zhang
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jianye DaiAiping Lu
Jun 13, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Shujun SunYongyu Zhang
Jul 3, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Zhan ZhengDaniel Man-Yuen Sze
Oct 27, 2015·Biomarkers in Medicine·Yufeng LiuXiaohui Fan
Jan 25, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jian LiAiping Lu
Apr 27, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Cheng LuAiping Lu
Jun 6, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Shuhao YuShi-Bing Su
May 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Hung-Tsu ChengIan C Hsu
May 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jie WangXingjiang Xiong
Nov 8, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Duong Duc PhamChae Hun Leem
Oct 19, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Marcus GadauChris Zaslawski
Sep 1, 2017·International Journal of Molecular Sciences·Min LiJianxin Wang
May 3, 2014·Molecular Medicine Reports·Xiuhui WangBeigang Fu
Jan 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huanyu GuanYue Shi
Dec 31, 2016·Chinese Journal of Integrative Medicine·Bum Ju LeeJong Yeol Kim
May 20, 2020·Drug Design, Development and Therapy·ZhongHua LeiBo Yu

❮ Previous
Next ❯

Software Mentioned

SAS
Agilent Literat
Biological Network Gene Ontology ( BiNGO )
LPAAT
IPCA
SAS9
IntAct
THETA
LOWESS
BiNGO

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.