Cold and Hot Gelling of Alginate-graft-PNIPAM: a Schizophrenic Behavior Induced by Potassium Salts

Biomacromolecules
Hui GuoDominique Hourdet

Abstract

Recently, alginates (ALG) characterized by high mannuronic content (M blocks) have been shown to undergo a reversible sol/gel transition during cooling in the presence of potassium salts. Cold gelling takes place at low temperatures, just below 0 °C for a KCl concentration of 0.3 mol/kg, but the aggregation process can be easily shifted to higher temperatures by increasing the salt concentration. In the present paper, we take advantage of this peculiar behavior to design a copolymer with schizophrenic gelling properties. For this purpose, side chains of poly(N-isopropylacrylamide) (PNIPAM), characterized by a Lower Critical Solution Temperature (LCST) in water, were grafted on the alginate backbone. Working in semidilute solutions, we show by coupling DSC and viscoelastic measurements that ALG-g-PNIPAM solutions are able to form gels either by cooling or heating depending on the ionic environment. As the aggregation process of ALG and PNIPAM depends mainly and respectively on the nature of the cations and anions, the choice of the salt is then critical to control the self-assembly behavior and the gel properties. Moreover, as the gelation process of alginates driven by the aggregation of mannuronic sequences is characterized by...Continue Reading

References

Jan 1, 1986·Journal of Biomedical Materials Research·W Cook
Jun 18, 2003·Biomaterials·L WangJ E Barralet
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eve Ruel-Gariépy, Jean-Christophe Leroux
Oct 13, 2005·Journal of the American Chemical Society·Yanjie ZhangPaul S Cremer
Aug 2, 2006·Macromolecular Bioscience·Alexander D AugstDavid J Mooney
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leda Klouda, Antonios G Mikos
Oct 12, 2010·Biomacromolecules·C KarakasyanD Hourdet
Apr 24, 2013·Chemical Society Reviews·Prathamesh M KharkarApril M Kloxin
Oct 24, 2013·Biomacromolecules·Joseph C WhiteSurita R Bhatia
Jun 7, 2017·Bone Research·Mei LiuNongyue He
Aug 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing JingRachel Auzély-Velty
Nov 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jatin N KumarShalen X L Aik

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Citations

Oct 3, 2020·Biomaterials Science·Mahsa ShahriariMona Alibolandi
May 1, 2021·International Journal of Molecular Sciences·Konstantinos SafakasConstantinos Tsitsilianis
Apr 25, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Natalya S VishnevetskayaChristine M Papadakis

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