PMID: 518180Dec 1, 1979Paper

Cold blood as the vehicle for potassium cardioplegia

The Annals of Thoracic Surgery
H B BarnerV L Willman

Abstract

Cold blood with potassium, 34 mEq/L, was compared with cold blood and with a cardioplegic solution. Three groups of 6 dogs had 2 hours of aortic cross-clamp while on total bypass at 28 degrees C with the left ventricle vented. An initial 5-minute coronary perfusion was followed by 2 minutes of perfusion every 15 minutes for the cardioplegic solution (8 degrees C) and every 30 minutes for 3 minutes with cold blood or cold blood with potassium (8 degrees C). Hearts receiving cold blood or cold blood with potassium had topical cardiac hypothermia with crushed ice. Peak systolic pressure, rate of rise of left ventricular pressure, maximum velocity of the contractile element, pressure volume curves, coronary flow, coronary flow distribution, and myocardial uptake of oxygen, lactate, and pyruvate were measured prior to ischemia and 30 minutes after restoration of coronary flow. Myocardial creatine phosphate (CP), adenosine triphosphate (ATP), and adenosine diphosphate (ADP) were determined at the end of ischemia and after recovery. Changes in coronary flow, coronary flow distribution, and myocardial uptake of oxygen and pyruvate were not significant. Peak systolic pressure and lactate uptake declined significantly for hearts perfused...Continue Reading

References

Jan 1, 1979·The Annals of Thoracic Surgery·V W Fischer, H B Barner
Dec 1, 1976·The Annals of Thoracic Surgery·R M EngelmanF Kaplan
Dec 1, 1975·Circulation Research·S A Glantz, R S Kernoff
Nov 1, 1972·Progress in Cardiovascular Diseases·J R NeelyJ F Oram
Sep 1, 1970·Journal of Applied Physiology·M JellinekG C Kaiser
Jul 2, 1955·Lancet·D G MELROSEJ B BAKER

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Citations

Mar 1, 1980·The Annals of Thoracic Surgery·H B BarnerV L Willman
Apr 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·O KatayamaM H Yacoub
May 1, 1983·The Annals of Thoracic Surgery·G L HicksR A DeWall
Dec 1, 1983·The Annals of Thoracic Surgery·R E ClarkS Boe
May 1, 1987·The Annals of Thoracic Surgery·J EugeneN J Haiduc
Jul 13, 2000·The Annals of Thoracic Surgery·Y HayashiH Matsuda
Dec 1, 1979·The American Journal of Cardiology·D H TyrasV L Willman
Jan 25, 1985·The American Journal of Cardiology·R E ClarkP D Henry
Jun 1, 1982·The Journal of Surgical Research·M J O'NeillR Hawkins
Jan 1, 1983·The Annals of Thoracic Surgery·K V AromD M Nicoloff
Mar 1, 1982·The Annals of Thoracic Surgery·F P CatinellaF C Spencer
Aug 1, 1986·The Annals of Thoracic Surgery·F OgumaS Eguchi
Dec 1, 1991·The Annals of Thoracic Surgery·H B Barner
Feb 1, 1985·The Annals of Thoracic Surgery·J E CoddV L Willman
Jan 1, 1981·The Annals of Thoracic Surgery·R E ClarkB E Sobel
Jan 1, 1982·The Annals of Thoracic Surgery·H B BarnerJ W Hahn
Aug 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·J A GatellK Shevde
Jan 1, 1991·Perfusion·C Munsch
Jan 1, 1980·Scandinavian Journal of Thoracic and Cardiovascular Surgery. Supplementum·J Jalonen
Sep 1, 1986·Journal of Cardiac Surgery·A S WechslerJ P Goldstein

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