Cold-induced pain and prickle in the glabrous and hairy skin

Pain
Karen D Davis

Abstract

Little is known concerning the mechanisms underlying the perception of cold pain in humans. An appreciation of these mechanisms is important to understand and possibly treat those disorders in which cold stimuli evoke unpleasant sensations. To study cold pain, I have conducted psychophysical experiments on 16 healthy subjects. A peltier-type stimulator (20 x 25 mm) was used to deliver stimuli to sites on the thenar eminence (glabrous skin) and volar forearm (hairy skin) of each arm. Each trial consisted of a 90 s, 2 degrees C stimulus that was preceded and followed by a 35 degrees C stimulus. A computer-based visual analog scale was used to collect continuous pain ratings throughout each trial. In experiment 1, nine subjects rated the overall evoked pain intensity (four trials/skin type) and the prickle component (four trials/skin type). Typically, subjects perceived the cold-evoked pain as prickly, cold/freezing and achy. The pain intensity and quality was similar for glabrous and hairy skin sites within individual subjects. Pain intensity gradually rose to a plateau by approximately 60 s into each trial. The prickle component differed amongst subjects due to its variable time course. Subjects consistently reported an intense,...Continue Reading

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