Cold-inducible RNA-binding protein-derived peptide C23 attenuates inflammation and tissue injury in a murine model of intestinal ischemia-reperfusion

Surgery
Joseph McGinnPing Wang

Abstract

Cold-inducible RNA-binding protein is a novel damage-associated molecular pattern that causes inflammation. C23, a short peptide derived from cold-inducible RNA-binding protein, has been found to have efficacy in blocking cold-inducible RNA-binding protein's activity. We hypothesized that C23 reduces inflammation and tissue injury induced by intestinal ischemia-reperfusion. Male C57BL/6 mice were subjected to 60 minutes of intestinal ischemia by clamping the superior mesenteric artery. Immediately after reperfusion, either normal saline (vehicle) or C23 peptide (8 mg/kg body weight) was injected intraperitoneally. Four hours after reperfusion, blood, intestinal, and lung tissues were collected for analysis of inflammatory and tissue injury parameters. Cold-inducible RNA-binding protein levels in the intestinal tissues were significantly increased following intestinal ischemia-reperfusion. Histologic examination of the intestine revealed a significant reduction in injury score in the C23 group by 48% as compared with the vehicles after intestinal ischemia-reperfusion. The serum levels of lactate dehydrogenase and aspartate aminotransferase were increased in animals that underwent vehicle-treated intestinal ischemia-reperfusion, ...Continue Reading

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Citations

Jan 16, 2019·Journal of Leukocyte Biology·Monowar AzizPing Wang
Jul 28, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Johan LindersHenrik Thorlacius
Nov 19, 2019·Frontiers in Immunology·Naomi-Liza DenningPing Wang
Feb 16, 2021·Antioxidants & Redox Signaling·Mian ZhouPing Wang
Aug 10, 2021·Frontiers in Immunology·Siavash BolouraniPing Wang
Dec 26, 2021·Journal of Cellular and Molecular Medicine·Peng ZhongHe Huang

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