Nov 14, 2013

Cold-inducible RNA-binding protein is an important mediator of alcohol-induced brain inflammation

PloS One
Salil R RajayerPing Wang

Abstract

Binge drinking has been associated with cerebral dysfunction. Ethanol induced microglial activation initiates an inflammatory process that causes upregulation of proinflammatory cytokines which in turn creates neuronal inflammation and damage. However, the molecular mechanism is not fully understood. We postulate that cold-inducible RNA-binding protein (CIRP), a novel proinflammatory molecule, can contribute to alcohol-induced neuroinflammation. To test this theory male wild-type (WT) mice were exposed to alcohol at concentrations consistent to binge drinking and blood and brain tissues were collected. At 5 h after alcohol, a significant increase of 53% in the brain of CIRP mRNA was observed and its expression remained elevated at 10 h and 15 h. Brain CIRP protein levels were increased by 184% at 10 h and remained high at 15 h. We then exposed male WT and CIRP knockout (CIRP(-/-)) mice to alcohol, and blood and brain tissues were collected at 15 h post-alcohol infusion. Serum levels of tissue injury markers (AST, ALT and LDH) were significantly elevated in alcohol-exposed WT mice while they were less increased in the CIRP(-/-) mice. Brain TNF-α mRNA and protein expressions along with IL-1β protein levels were significantly incr...Continue Reading

Mentioned in this Paper

Cerebral Dysfunction Syndrome
Neuro-Oncological Ventral Antigen 2
Real-Time Polymerase Chain Reaction
Brain Injuries
CIRBP gene
Ethanol
Salicylhydroxamic acid
Tissue Membrane
Tumor Necrosis Factor-alpha
TLR4 gene

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