Cold ischaemia, innate immunity and deterioration of the glomerular filtration barrier in antibody-mediated acute rejection

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Èlia RipollI Herrero-Fresneda

Abstract

In renal transplantation, cold ischaemia (CI) determines acute rejection through innate immunity among others. Acute rejection episodes are a risk factor for late allograft dysfunction and proteinuria. This implies some alteration of the glomerular filtration barrier (GFB). Besides its effects on acute rejection, we hypothesized that CI might somehow damage the GFB being directly responsible for late proteinuria. On rat kidney allografts suffering from antibody-mediated acute rejection with or without CI and compared with syngeneic grafts, we quantified the gene expression of innate and adaptive immune mediators and assessed the capillary glomerular basement membranes (CapBM) by immunostaining collagen-IV (ColIV). ColIV was also assessed in equivalent groups from a previous chronic study followed up for 24 weeks. CI up-regulated enzymes critical in the stabilization of collagen chains, increasing ColIV deposition and thickening the CapBM. CI increased the C4d and IgG deposits within grafts, amplified innate immunity (heat shock protein 70, fibronectin, Toll-like-receptor-4 and MyD88) and synergized with alloreactivity in triggering adaptive response through CD40. Initial CI increased the ColIV deposition in CapBM, damaging the ...Continue Reading

References

Nov 1, 1995·Stroke; a Journal of Cerebral Circulation·G F HamannG J del Zoppo
Dec 16, 1998·Kidney International·S J HarveyP S Thorner
Sep 1, 1999·Kidney International·L C Paul
May 9, 2000·The Journal of Biological Chemistry·Y TakahashiT Miura
Jun 15, 2000·The American Journal of Pathology·L HeidetM C Gubler
Jan 21, 2001·The Journal of Biological Chemistry·Y OkamuraJ F Strauss
Jan 13, 2001·Current Opinion in Immunology·S Gallucci, P Matzinger
Mar 7, 2001·Kidney International·E A KouwenhovenJ N Ijzermans
Jul 17, 2001·Transplantation·K UtsumiT Sawada
Dec 18, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·B IvanyiP Szenohradszky
Mar 22, 2002·Nature Reviews. Immunology·M Wills-KarpC L Karp
Apr 12, 2002·The American Journal of Pathology·Simone A JoostenLeendert C Paul
Jun 18, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Akira ShimizuRobert B Colvin
Aug 8, 2002·Archives of Histology and Cytology·Norio UrabeYoshifumi Ninomiya
Jan 1, 2003·The American Journal of Pathology·Immaculada Herrero-FresnedaJosep M Grinyo
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Paul A Nony, Rick G Schnellmann
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lorraine C RacusenKiril Trpkov
Feb 18, 2004·Transplantation·Benjamin SamsteinJeffrey L Platt
May 18, 2004·The Journal of Clinical Investigation·Jochen ReiserPeter Mundel
Jul 15, 2004·Transplantation Proceedings·P LoiV Flamand
Dec 9, 2004·International Immunology·Kiyoshi Takeda, Shizuo Akira
Apr 9, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Cristiano Feijó AndradeMingyao Liu
May 25, 2005·Transplantation·Byung Soo KimChul Woo Yang
Jun 16, 2005·Kidney International·Simone A JoostenLeendert C Paul
Jul 16, 2005·Molecular Immunology·Heiko Hawlisch, Jörg Köhl
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P Boros, J S Bromberg
Apr 29, 2006·The Journal of Biological Chemistry·Yen-Chiu Lin-LeeRichard J Ford
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G WieczorekV Nickeleit
Nov 14, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Cristiano Feijó AndradeMingyao Liu
Dec 13, 2006·Transplant Immunology·Daniel R Goldstein
Sep 15, 2007·The Journal of Clinical Investigation·Huiling WuSteven J Chadban
Jan 26, 2008·Microscopy Research and Technique·Jamshid KhoshnoodiBilly G Hudson
Mar 21, 2008·Journal of the American Society of Nephrology : JASN·Mauro AbbateGiuseppe Remuzzi
May 27, 2008·Nature Reviews. Immunology·Aja Rieger, Amit Bar-Or
Jun 28, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffery T FletcherStephen I Alexander
Jul 16, 2008·Transplantation·Maria-Luisa AlegreMichel Goldman
Apr 18, 2009·Current Opinion in Nephrology and Hypertension·George Jarad, Jeffrey H Miner
Jul 11, 2009·Nephron. Clinical Practice·James FotheringhamWilliam McKane
Aug 12, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiuda ShenYuan Zhai

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Citations

Apr 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Uwe Heemann, Jens Lutz
Oct 20, 2012·Current Opinion in Organ Transplantation·Lutz Renders, Uwe Heemann

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